Tissue-specific modifications in the human ADRB2 gene. DGG blot made using RsaI-digested DNA isolated from various tissues from single individuals, electrophoresed in a 20–80% DGG for 1500 volt-hours (VH), and hybridized with a 2.0 kb EcoRI ADRB2 cDNA fragment. B = blood leukocyte, S = sperm, Om = omentum, Sk = skin, RL = round ligament, FT = fallopian tube, OT = malignant ovarian tumor, F = fibroid, Ov = ovary, Mu = muscle, Myo = myometrium. Numbers indicate individual patients from whom tissues were collected.