Table 1.

Psychomotor and Cognitive Test Results (8 Hours Postnocturnal Dosing)

Parameter, Unit (SEM)	Placebo	Original Zolpidem 10 mg	Zolpidem Extended-Release 12.5 mg
CFF, hertz – measure of attention and sedation. Subjects are required to discriminate flicker from fusion, and vice versa, in a set of 4 light-emitting diodes arranged in a 1-cm square.	30.88 (0.47)	30.74 (0.48)	30.53 (0.46)
WRd, number correct – measure of delayed memory. Subjects are given 2 minutes to learn a list of 20 words. Thirty minutes after this learning period, subjects are given a 2-minute free-recall period, during which they write down as many of the words as they can remember.	11.09 (0.91)	10.11 (0.80)	10.21 (0.80)
WRi, number correct – measure of immediate memory. Subjects are given 2 minutes to learn a list of 20 words immediately followed by a 2-minute free-recall period, during which they write down as many of the words as they can remember.	15.26 (0.65)	14.83 (0.67)	14.91 (0.62)
CRT total reaction time, milliseconds – measure of attention and sedation. Subjects are required to extinguish 1 of 6 equidistant red lights by pressing an associated response button as quickly as possible.	605.58 (17.69)	617.64 (17.87)	619.56 (17.98)

SEM = standard error of mean; CFF = critical flicker fusion frequency; WRd = delayed word recall; WRi = immediate word recall; CRT = choice reaction time Adapted from Hindmarch et al[23]