Table 2.
Breakthrough fungal infections
| AMB Period vs. AZ Period | ||||
| AMB (n = 259) | AZ (n = 321) | Odds Ratio1 | p-value2 | |
| Any Fungal Infection | 27 (10.4%) | 44 (13.7%) | OR = 1.38 | 0.23 |
| Possible | 18 (6.9%) | 37 (11.5%) | ||
| Probable/Definite | 9 (3.5%) | 7 (2.2%) | ||
| Aspergillus | 5 (1.9%) | 2 (0.6%) | OR = 0.33 | 0.19 |
| Candida | 4 (1.5%) | 5 (1.6%) | OR = 0.97 | 0.97 |
1Odds ratios are from random effects regression models that controlled for the number of hospitalizations. The reported odds ratios are the odds of having a breakthrough infection in the AZ period relative to the AMB period
2p-values are from random effects logistic regression models that controlled for the number of hospitalization
*Two patients in the FLU group had both Aspergillus and Candida infections in the same hospitalization
*Of the two patients in the AZ group who had probable/definite breakthrough Aspergillus infection, one patient received FLU and the other received VOR
Note: AMB = amphotericin; AZ = Azole; FLU = fluconazole; VOR = voriconazole