Table 2.
Expression profile of lymphangioma LECs compared to HUVECs using Agilent gene micro-arrays
| Molecule | Patient A | P-Value | Patient B | P-Value |
| LEC markers | ||||
| Prox1 | 5.21 | 3.2779e-05 | 5.34 | 3.0458e-05 |
| 5.00 | 0.000114 | 5.47 | 8.7549e-05 | |
| Podoplanin | 7.26 | 0.000538 | 6.23 | 0.000847 |
| Reelin | 5.64 | 0.000634 | 5.12 | 0.000844 |
| c-Maf | 4.45 | 0.000177 | 5.17 | 0.000113 |
| Macrophage mannose receptor | 3.96 | 0.000157 | 4.48 | 0.000109 |
| TIMP 3 | 5.60 | 2.3392e-05 | 5.80 | 2.1012e-05 |
| Lyve-1 | 2.75 | 0.001547 | 1.89 | 0.004617 |
| VEGFR-3 | 1.73 | 0.009537 | 2.38 | 0.003869 |
| 2.54 | 0.000704 | 3.30 | 0.000323 | |
| Growth factors and receptors | ||||
| VEGFR-2 | 1.91 | 0.005006 | 4.18 | 0.000506 |
| 1.33 | 0.085223 | 4.08 | 0.004490 | |
| Neuropilin-2 | 1.59 | 0.000646 | 2.89 | 0.000107 |
| 1.47 | 0.001513 | 3.34 | 0.000133 | |
| 1.19 | 0.009847 | 3.09 | 0.000614 | |
| FGF-12 | 1.56 | 0.001699 | 2.67 | 0,000344 |
| 0.98 | 0.005359 | 2.59 | 0,000304 | |
| TGF-α | 5.03 | 0.000273 | 5.32 | 0.000230 |
| Integrin-α9 | 2.46 | 0.000592 | 2.35 | 0.000677 |
| 1.15 | 0.002815 | 1.70 | 0.000912 | |
| Integrin-α1 | 4.22 | 0.003322 | 2.69 | 0.011953 |
| VEGFR-2 and -3 signalling | ||||
| SHC | 2.34 | 0.000219 | 3.20 | 8.6303e-05 |
| 1.73 | 0.000303 | 2.50 | 0.000100 | |
| PLCγ-1 | 1.80 | 0.000291 | 0.69 | 0.004961 |
| PLCγ-2 | n.r. | - | 1.27 | 0.005680 |
| MAPK3/ERK1 | 0.40 | 0.029350 | 1.63 | 0.000559 |
| MAPK1/ERK2 | -0.84 | 0.005289 | -0.62 | 0.012707 |
| -0.45 | 7.9235e-06 | -0.21 | 8.2757e-05 | |
| NF-kappaB1 | 0.27 | 0.026460 | 0.85 | 0.000982 |
| 0.29 | 0.047104 | 1.16 | 0.001010 |
The up-regulation is expressed as the log2 ratio as compared to HUVECs. For MAPK1 we observed down-regulation. All values (except one written in italic) are statistically significant. Double values refer to transcription variants of the gene. n.r. = not regulated.