Table 1.
Sepsis accomplished by abdominal surgery comprising coecal ligation and puncture with a 1,2 mm needle (CLP), or sham surgery + pre-treatment with 1,25 vit-D or vehicle.
| Control +vehicle | Control + 1,25 vit-D | Sham- operation +vehicle | Sham- operation + 1,25 vit-D | CLP +vehicle | CLP + 1,25 vit-D | |
|---|---|---|---|---|---|---|
| n= | 8 | 8 | 8 | 8 | 8 | 8 |
| Thrombocytes (109/L) | 647 ± 95 | 606 ± 139 | 631 ± 48 | 551 ± 53 | 418 ± 49 b | 515 ± 53 c |
| PT (seconds) | 12,0 ± 0,2 | 12,2 ± 0,7 | 11,4 ± 0,6 | 11,0 ± 0,8 | 12,5 ± 1,2 | 12,7 ± 1,0 |
| ALT (units/L) | 53 ± 7 | 53 ± 8 | 59 ± 13 | 64 ± 5 | 71 ± 17 | 77 ± 13 b |
| Bilirubin (µmol/L) | 0,68 ± 0,29 | 0,62 ± 0,27 | 1,23 ± 0,11 a | 0,73 ± 0,39 c | 3,51 ± 1,87 b | 2,36 ± 1,14 b |
| Creatinine (µmol/L) | 41 ± 7 | 46 ± 19 | 46 ± 14 | 36 ± 3 | 40 ± 2 | 42 ± 5 |
| Urea (µmol/L) | 8,2 ± 0,5 | 8,4 ± 0,7 | 7,0 ± 0,5 a | 6,5 ± 0,6 a | 6,9 ± 0,8 | 8,9 ± 2,6 |
| Ca++(7,4) (mmol/L) | 1,34 ± 0,02 | 1,36 ± 0,02 | 1,35 ± 0,02 | 1,35 ± 0,02 | 1,26 ± 0,06 b | 1,28 ± 0,03 b |
a Significant effect of sham operation vs control. (P<0,05)
b Significant effect of CLP vs. sham operation. (P<0,05)
c Significant effect of 1,25 vit-D vs. vehicle. (P<0,05).