Table 2.
Sepsis accomplished by a single IP injection of lipopolysaccharide from E. Coli 0111:B4 8 mg/kg (LPS), or control + pre-treatment with 1,25 vit-D or vehicle.
| Controls +vehicle | Controls +1,25 vit-D | LPS + vehicle | LPS +1,25 vit-D | ||
|---|---|---|---|---|---|
| n= | 8 | 8 | 6 | 6 | |
| Thrombocytes (109/L) | 647 ± 95 | 606 ± 139 | 259 ± 198 a | 208 ± 214 a | |
| PT (seconds) | 12,0 ± 0,2 | 12,2 ± 0,7 | 11,4 ± 0,4 a | 12,0 ± 0,4 | |
| ALT (units/L) | 53 ± 7 | 53 ± 8 | 124 ± 167 | 94 ± 24 a | |
| Bilirubin (µmol/L) | 0,68 ± 0,29 | 0,62 ± 0,27 | 1,77 ± 1,10 | 2,12 ± 0,53 a | |
| Creatinine (µmol/L) | 41 ± 7 | 46 ± 19 | 44 ± 7 | 57 ± 11 | |
| urea (µmol/L) | 8,2 ± 0,5 | 8,4 ± 0,7 | 10,66 ± 3,09 | 11,90 ± 2,47 a | |
| Ca++(7,4) (mmol/L) | 1,34 ± 0,02 | 1,36 ± 0,02 | 1,36 ± 0,02 | 1,37 ± 0,02 | |
a Significant effect of LPS vs control. (P<0,05).
No significant effects (P<0,05) of 1,25 vit-D were seen in this study.