Table 3.
Sepsis accomplished by an hour-long IV infusion of lipopolysaccharide from E. Coli 0111:B4 7 mg/kg (LPS), or control + pre-treatment with 1,25 vit-D or vehicle.
| Control +vehicle | Control + 1,25 vit-D | LPS + vehicle | LPS + 1,25 vit-D | |
|---|---|---|---|---|
| n= | 6 | 8 | 10 | 10 |
| Thrombocytes (109/L) | 1056 ± 196 | 980 ± 260 | 480 ± 80 a | 415 ± 63 a |
| PT (seconds) | 21,4 ± 3,5 | 17,9 ± 2,0 | 29,8 ± 6,1 | 26,6 ± 3,6 a |
| ALT (units/L) | 53 ± 18 | 78 ± 30 | 66 ± 8 | 93 ± 33 |
| Bilirubin (µmol/L) | 1,27 ± 0,35 | 1,27 ± 0,13 | 2,66 ± 0,65 a | 3,26 ± 0,60 a |
| Creatinine (µmol/L) | 55 ± 4 | 62 ± 5 b | 76 ± 6 a | 103 ± 19 a,b |
| Urea (µmol/L) | 6,3 ± 1,1 | 7,8 ± 0,7 | 11,8 ± 0,8 a | 13,3 ± 1,0 a,b |
| Ca++(7,4) (mmol/L) | 1,34 ± 0,02 | 1,42 ± 0,05 b | 1,24 ± 0,04 a | 1,28 ± 0,04 a |
a Significant effect of LPS vs. controls. (P<0,05)
b Significant effect of 1,25 vit-D vs. vehicle. (P<0,05).