Table 1.
Characteristic of adolescents with depression according to allocated treatment with selective serotonin reuptake inhibitors (SSRIs) alone or in combination with cognitive behaviour therapy (CBT). Figures are numbers (percentages) of patients unless stated otherwise
| SSRI (n=103) | CBT plus SSRI (n=105) | |
|---|---|---|
| Female | 75 (73) | 79 (75) |
| Median (range) age (years) | 14 (11-17) | 14 (11-17) |
| Study centre: | ||
| Manchester | 74 (72) | 75 (71) |
| Cambridge | 29 (28) | 30 (29) |
| Behavioural disorder | 30 (29) | 33 (31) |
| CGAS >40 | 58 (56) | 49 (47) |
| Mean (SD) depressive symptoms | 6.6 (1.5) | 6.4 (1.4) |
| Comorbid diagnosis: | ||
| Social phobia | 49 (48) | 43 (41) |
| Obsessive compulsive disorder | 37 (36) | 42 (40) |
| Post-traumatic stress disorder | 36 (35) | 42 (40) |
| Agoraphobia | 29 (28) | 36 (34) |
| Separation anxiety disorder | 28 (27) | 31 (29) |
| Specific phobia | 22 (22) | 25 (26) |
| Conduct disorder | 17 (17) | 18 (17) |
| Panic disorder (without agoraphobia) | 14 (14) | 21 (20) |
| Oppositional defiance disorder | 13 (13) | 17 (16) |
| Generalised anxiety disorder | 13 (13) | 19 (18) |
| Panic disorder (with agoraphobia) | 13 (13) | 20 (19) |
| ADHD | 6 (6) | 5 (5) |
| Bulimia nervosa | 4 (4) | 8 (8) |
| Alcohol abuse | 4 (4) | 1 (1) |
| Transient tic disorder | 3 (3) | 2 (2) |
| Tourette's syndrome | 2 (2) | 2 (2) |
| Alcohol dependence | 2 (2) | 1 (1) |
| Chronic motor or vocal tic disorder | 1 (1) | 2 (2) |
| Anorexia nervosa | 0 | 1 (1) |
| Encopresis | 0 | 1 (1) |
| Enuresis | 0 | 1 (1) |
| Dysthymia | 0 | 1 (1) |
CGAS=children's global assessment scale; ADHD=attention deficit hyperactivity disorder.