Table 1.

Hormonal characteristics by diagnosis and Pro12Ala genotype.

	Controls			PCOS
	C/C	C/G or G/G	P-Value	C/C	C/G or G/G	P-Value
	n=134	n=34		n=213	n=54
Age (yr)	33.6 ± 11.5	37.7 ± 11.7	0.076	27.6 ± 7.4	27.1 ± 7.3	0.72
Body mass index (kg/m2)	25.6 ± 5.8	25.8 ± 6.3	0.73	34.9 ± 9.1	34.5 ± 9.9	0.88
Waist/Hip ratio	0.79 ± 0.06	0.79 ± 0.07	0.37	0.84 ± 0.08	0.85 ± 0.13	0.30
Hirsutism (%)	0	0	n/a	75	69	0.32
Ferriman-Gallwey Score	0.16 ± 0.46	0.09 ± 0.29	0.54	8.34 ± 4.83	7.80 ± 5.05	0.39
Total Testosterone [ng/dL	46.4 ± 21.1	37.7 ± 18.3	0.058	86.1 ± 31.1	78.1 ± 25.5	0.11
(nmol/L)]	(1.61 ± 0.73)	(1.31 ± 0.63)		(2.98 ± 1.08)	(2.71 ± 0.88)
Free Testosterone [pg/mL	0.40 ± 0.19	0.34 ± 0.19	0.12	0.92 ± 0.41	0.87 ±0.33	0.51
(pmol/L)]	(13.87 ± 6.59)	(11.79 ± 6.59)		(31.90 ± 14.21)	(30.16 ± 11.44)
DHEAS (ng/mL)	1137.4 ± 778.4	992.7 ± 726.9	0.84	2241.9 ± 1270.5	2383.1 ± 1261.9	0.41
SHBG (nmol/L)	224.9 ± 81.5	227.1 ± 78.7	0.66	171.5 ± 61.9	173.5 ± 82.7	0.90

Note: Comparisons are made between the 2 genotypes within each group, using logistic regression (hirsutism) or analysis of covariance (other traits). Multiple testing-corrected P value<0.01 is significant. Values expressed with a plus/minus sign are mean ± SD.