Table 4.

Metabolic characteristics by diagnosis and His447His genotype.

	Controls			PCOS
	C/C	C/T or T/T	P-Values	C/C	C/T or T/T	P-Values
	n= 73	n= 23		n= 153	n= 42
Age (yr)	35.7 ± 13.9	36.0 ± 10.2	0.99	27.0 ± 7.1	28.0 ± 8.0	0.54
Body mass index (kg/m2)	26.4 ± 6.2	27.0 ± 6.4	0.72	35.5 ± 9.3	37.2 ± 9.1	0.36
Fasting Insulin [μIU/mL	9.4 ± 6.2	7.0 ± 8.0	0.014	20.4 ± 15.6	24.6 ± 16.8	0.16
(pmol/L)]	(67.4 ± 44.8)	(56.0 ± 57.3)		(144.5 ± 112.0)	(176.6 ± 120.8)
Fasting Glucose [mg/dL	87.4 ± 11.2	85.3 ± 9.7	0.43	87.7 ± 10.7	89.2 ± 11.8	0.68
(mmol/L)	(4.85 ± 0.62)	(4.74 ± 0.54)		(4.87 ± 0.59)	(4.95 ± 0.66)
HOMA-IR	1.27 ± 0.82	1.03 ± 1.06	0.0056	2.28 ± 1.41	2.82 ± 1.54	0.090
HOMA-%B	117.5 ± 50.7	100.8 ± 37.0	0.13	175.9 ± 85.8	201.2 ± 96.0	0.15

Note: Comparisons are made between the 2 genotypes within each group, using logistic regression (hirsutism) or analysis of covariance (other traits). Multiple testing-corrected P value<0.01 is significant. Values are mean ± SD.