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Three distinct pathways resulting in spliceosome assembly. Under typical splicing conditions, both U2AF and U1 snRNP are required for spliceosome assembly with a network of stabilizing interactions between U2AF, U1 snRNP, and SR proteins (B; ref. 20). In a substrate-specific manner, excess SC35 reconstitutes splicing in U2AF-depleted reactions in a U1 snRNP-dependent pathway (A) and in U1 snRNP-depleted reactions in a U2AF-dependent pathway (C).
