Figure 2.

(a) Primer extension analysis of HeLa cell RNA showing the transcriptional start site in relation to the sequence of the p62^cdc6 gene cloned from human chromosome 17. The positions of putative transcriptional control elements (initiator element and potential E2F binding sites) are indicated. (b) Nucleotide sequence of proximal promoter region and exon 1 of human gene encoding p62^cdc6. Putative transcriptional control elements are indicated in boldface type, and restriction sites are underlined. The first nucleotide (+1) in the cloned p62^cdc6 cDNA is shown, and a putative splice junction is present at the point where the genomic sequence diverges from that of the cloned cDNA, defining exon 1.