Table 1.
Genes differentially regulated in ectopic and eutopic endometrium of a rat model of endometriosis
| NAME (by fold-expression) | Fold-expression | % SDa | Previously shown to be associated to human endometriosis |
|---|---|---|---|
| MMP12: (MMP12 OR HME) MACROPHAGE METALLOELASTASE PRECURSOR | 70.13 | 7 % | |
| MMP9: (MMP9 OR CLG4B) 92 KDA TYPE IV COLLAGENASE PRECURSOR | 24.33 | 22 % | 46–50 |
| OPN: (SPP1 OR OPN) OSTEOPONTIN PRECURSOR (BONE SIALOPROTEIN 1 | 24.14 | 3 % | 51 |
| MMP13: (MMP13) COLLAGENASE 3 PRECURSOR | 22.30 | 74 % | |
| FABE: (FABP5 OR MAL1 OR KLBP OR FABPE) FATTY ACID-BINDING PROTEIN, EPIDERMAL (E-FABP) | 14.55 | 7 % | |
| CCL3_RAT: (CCL3 OR SCYA3 OR G0S19-1 OR MIP1A) SMALL INDUCIBLE CYTOKINE A3 PRECURSOR (CCL3) (MACROPHAGE INFLAMMATORY PROTEIN 1-ALPHA) | 13.78 | 30 % | |
| ITGB2: (ITGB2 OR CD18) INTEGRIN BETA-2 PRECURSOR (CELL SURFACE ADHESION GLYCOPROTEINS LFA-1/CR3/P150,95 BETA-SUBUNIT | 13.67 | 11 % | 52 |
| CCL9_RAT: (SCYA9 OR SCYA10 OR MRP2) SMALL INDUCIBLE CYTOKINE A9 PRECURSOR (MACROPHAGE INFLAMMATORY PROTEIN 1-GAMMA) (MIP-1-GAMMA) | 12.35 | 20 % | |
| FABI: (FABP2) FATTY ACID-BINDING PROTEIN, INTESTINAL (I-FABP) (FABPI). | 10.26 | 57 % | |
| LBP: (LBP) LIPOPOLYSACCHARIDE-BINDING PROTEIN PRECURSOR (LBP). | 9.99 | 21 % | |
| DMBT1: (DMBT1) DMBT1 PROTEIN. EBNERIN. (CRPD OR CRP OR CRP-DUCTIN) CRP-DUCTIN PRECURSOR (CRP). | 9.36 | 5 % | |
| BCL2A1: (BCL2A1 OR BFL1 OR GRS OR BCL2L5) BCL2-RELATED PROTEIN A1 (BFL-1 PROTEIN) (HEMOPOIETIC-SPECIFIC EARLY RESPONSE PROTEIN) (GRS PROTEIN). | 9.14 | 16 % | 53–55 |
| S100A9: (S100A9 OR CAGB) CALGRANULIN B (MIGRATION INHIBITORY FACTOR-RELATED PROTEIN 14) (MRP-14) (P14) (LEUKOCYTE L1 COMPLEX HEAVY CHAIN) | 8.99 | 21 % | 56 |
| C3: (C3) COMPLEMENT C3 PRECURSOR. | 7.81 | 35 % | 18,57 |
| ITGAM: (ITGAM OR CR3A OR CD11B) INTEGRIN ALPHA-M PRECURSOR (CELL SURFACE GLYCOPROTEIN MAC-1 ALPHA SUBUNIT) (CR-3 ALPHA CHAIN) (CD11B) | 6.88 | 44 % | |
| CD36: (CD36 OR GP4 OR GP3B OR FAT) PLATELET GLYCOPROTEIN IV (GPIV) (GPIIIB) (CD36 ANTIGEN) (PAS-4 PROTEIN) | 6.70 | 14 % | |
| CTGF: (CTGF OR HCS24) CONNECTIVE TISSUE GROWTH FACTOR PRECURSOR (HYPERTROPHIC CHONDROCYTE-SPECIFIC PROTEIN 24). | 6.57 | 12 % | 58 |
| ANPEP: (ANPEP OR PEPN OR APN OR CD13 OR LAP1 OR LAP-1) AMINOPEPTIDASE N (MICROSOMAL AMINOPEPTIDASE) (GP150) | 6.48 | 5 % | |
| DUSP1: (DUSP1 OR PTPN10 OR MKP1 OR CL100 OR HVH1) DUAL SPECIFICITY PROTEIN PHOSPHATASE 1 (MAP KINASE PHOSPHATASE-1) (MKP-1) | 6.38 | 9 % | 59 |
| ATF3: (ATF3) CYCLIC-AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3 (ACTIVATING TRANSCRIPTION FACTOR 3). | 6.33 | 18 % | |
| FGR: (FGR OR SRC2) PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FGR (P55-FGR) (C-FGR). | 5.94 | 44 % | |
| LIPL: (LPL OR LIPD) LIPOPROTEIN LIPASE PRECURSOR (LPL). | 5.94 | 6 % | |
| TNC: (TNC OR HXB OR TN-C) TENASCIN PRECURSOR (TN) (CYTOTACTIN) (NEURONECTIN) (GLIOMA-ASSOCIATED-EXTRACELLULAR MATRIX ANTIGEN) | 5.90 | 14 % | 60 |
| INTEGRINB6: (ITGB6) INTEGRIN BETA-6 PRECURSOR. | 5.61 | 22 % | 19,61,62 |
| CXCR4: (CXCR4 OR LESTR OR CMKAR4 OR SDF1R) C-X-C CHEMOKINE RECEPTOR TYPE 4 (CXC-R4) (CXCR-4) (STROMAL CELL-DERIVED FACTOR 1 RECEPTOR) | 5.48 | 5 % | |
| SCYB1_RAT: (SCYB1 OR GRO1 OR GRO OR MGSA) GROWTH REGULATED PROTEIN PRECURSOR (CXCL1) (CYTOKINE-INDUCED NEUTROPHIL CHEMOATTRACTANT) (CINC-1) (PLATELET-DERIVED GROWTH FACTOR- INDUCIBLE PROTEIN KC) | 5.43 | 38 % | 63 |
| CXCL4_RAT: (SCYB4 OR PF4) PLATELET FACTOR 4 PRECURSOR (PF-4) (ONCOSTATIN A) | 4.92 | 8 % | |
| MUC1: (MUC1) MUCIN 1 PRECURSOR (MUC-1) (POLYMORPHIC EPITHELIAL MUCIN) (PEM) (PEMT) (TUMOR-ASSOCIATED MUCIN) (CARCINOMA-ASSOCIATED MUCIN) (TUMOR-ASSOCIATED EPITHELIAL MEMBRANE ANTIGEN) (EMA) | 4.92 | 22 % | 64,65 |
| CD53: (CD53 OR MOX44 OR OX-44) LEUKOCYTE SURFACE ANTIGEN CD53 (CELL SURFACE GLYCOPROTEIN CD53) (LEUKOCYTE ANTIGEN MRC OX-44). | 4.87 | 6 % | |
| MMP7: (MMP7 OR MPSL1 OR PUMP1) MATRILYSIN PRECURSOR (UTERINE METALLOPROTEINASE) (MATRIX METALLOPROTEINASE-7) (MMP-7) | 4.85 | 12 % | |
| S100A8: (S100A8 OR CAGA) CALGRANULIN A (MIGRATION INHIBITORY FACTOR-RELATED PROTEIN 8) (MRP-8) (CYSTIC FIBROSIS ANTIGEN) (CFAG) (P8) | 4.81 | 18 % | 56 |
| TNFRSF11B: (TNFRSF11B OR OPG OR OCIF) OSTEOPROTEGERIN PRECURSOR (OSTEOCLASTOGENESIS INHIBITORY FACTOR) (OCIF) (TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11B). | 4.81 | 23 % | 66 |
| CD3Z-CD3H: (CD3Z OR T3Z OR TCRZ) T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN PRECURSOR (T-CELL RECEPTOR T3 ZETA CHAIN) (CD3Z OR CD3H) | 4.74 | - % | |
| UPA: (PLAU) UROKINASE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (UPA) (U-PLASMINOGEN ACTIVATOR). | 4.71 | 8 % | 67,68 |
| CCL4: (SCYA4 OR MIP1B OR LAG1) SMALL INDUCIBLE CYTOKINE A4 PRECURSOR (MACROPHAGE INFLAMMATORY PROTEIN 1-BETA) (MIP-1-BETA) (T-CELL ACTIVATION PROTEIN 2) (ACT-2) | 4.54 | - % | |
| MOA-TF: (MITF OR MI) MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR (PUTATIVE TRANSCRIPTION FACTOR MI) | 4.42 | 40 % | |
| RAC2: (RAC2) RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2 (P21-RAC2) (SMALL G PROTEIN) (GX) | 4.31 | 7 % | |
| LUMICAN: (LDC) LUMICAN PRECURSOR (LUM) (KERATAN SULFATE PROTEOGLYCAN). | 4.27 | 19 % | |
| CD72: (LY-32 OR LYB-2 OR CD72) B-CELL DIFFERENTIATION ANTIGEN CD72 (LYB-2). | 4.23 | - % | |
| IL18: (IL18 OR IGIF) INTERLEUKIN-18 PRECURSOR (IL-18) (INTERFERON-GAMMA INDUCING FACTOR) (INTERLEUKIN-1 GAMMA) (IL-1 GAMMA). | 4.15 | 20 % | 69 |
| IL1B: (IL1B) INTERLEUKIN-1 BETA PRECURSOR (IL-1 BETA) (CATABOLIN). | 3.96 | 20 % | 70 |
| SELPLG: (SELPLG) P-SELECTIN GLYCOPROTEIN LIGAND 1 PRECURSOR (PSGL-1) (SELECTIN P LIGAND) (CD162 ANTIGEN). | 3.93 | 31 % | |
| THAS: (TBXAS1 OR CYP5) THROMBOXANE-A SYNTHASE (TXA SYNTHASE) (TXS). | 3.91 | 20 % | |
| THROMBOSPONDIN1: (THBS1 OR TSP1 OR TSP) THROMBOSPONDIN 1 PRECURSOR. | 3.88 | 16 % | 71 |
| CYP7B1: (CYP7B1) CYTOCHROME P450 7B1 (OXYSTEROL 7-ALPHA-HYDROXYLASE) | 3.83 | 27 % | |
| LYL1: (LYL1) LYL-1 PROTEIN. | 3.73 | 63 % | |
| TEF_BAD: (TEF) THYROTROPH EMBRYONIC FACTOR. | 3.67 | 89 % | |
| MMP11: (MMP11 OR STMY3) STROMELYSIN-3 PRECURSOR (MATRIX METALLOPROTEINASE-11) (MMP-11) | 3.66 | 14 % | |
| NDRG1: (NDRG1 OR NRD1 OR RTP OR DRG1 OR CAP43 OR NDRL OR TDD5) NDRG1 PROTEIN (DIFFERENTIATION-RELATED GENE 1 PROTEIN) (DRG1) | 3.60 | 9 % | |
| CD74: (CD74 OR DHLAG OR II) HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, GAMMA CHAIN (HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN) | 3.56 | 4 % | 16,18 |
| ALCAM: (ALCAM) CD166 ANTIGEN PRECURSOR (ACTIVATED LEUKOCYTE-CELL ADHESION MOLECULE) (ALCAM) | 3.50 | 5 % | |
| CD79A: (CD79A OR IGA OR MB1 OR MB-1) B-CELL ANTIGEN RECEPTOR COMPLEX ASSOCIATED PROTEIN ALPHA-CHAIN PRECURSOR (IG-ALPHA) | 3.49 | 12 % | |
| JUNB: (JUNB) TRANSCRIPTION FACTOR JUN-B (G0S3). | 3.48 | 4 % | |
| ASC: (ASC OR TMS1 OR PYCARD OR CARD5) APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN (TARGET OF METHYLATION-INDUCED SILENCING 1) (CASPASE RECRUITMENT DOMAIN PROTEIN 5). | 3.46 | 8 % | |
| VAV: (VAV) VAV PROTO-ONCOGENE | 3.46 | 15 % | |
| ITGA4: (ITGA4 OR VLA-4) INTEGRIN ALPHA-4 PRECURSOR (INTEGRIN ALPHA-IV) (VLA-4) (CD49D) (LYMPHOCYTE-PEYER’S PATCH ADHESION MOLECULES ALPHA SUBUNIT) (LPAM ALPHA SUBUNIT). | 3.43 | 13 % | |
| FBLN2: (FBLN2) FIBULIN-2 PRECURSOR. | 3.31 | 13 % | |
| COL11A1: (COL11A1) COLLAGEN ALPHA 1(XI) CHAIN PRECURSOR. | 3.28 | 26 % | 19,72,73 |
| IL2RG: (IL2RG) CYTOKINE RECEPTOR COMMON GAMMA CHAIN PRECURSOR (GAMMA-C) (INTERLEUKIN- 2 RECEPTOR GAMMA CHAIN) (IL-2R GAMMA CHAIN) (P64) (CD132 ANTIGEN). | 3.18 | 14 % | 22 |
| ZF9: (COPEB OR KLF6 OR BCD1 OR CPBP) CORE PROMOTER ELEMENT-BINDING PROTEIN (B-CELL DERIVED PROTEIN 1) (PROTO-ONCOGENE BCD1) | 3.16 | 7 % | |
| CCR5-CCR2: (CCR5 OR CMKBR5) C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (HIV-1 FUSION CO-RECEPTOR) (CHEMR13) | 3.09 | 29 % | |
| FIP2: (FIP2 OR NEMO2) TUMOR NECROSIS FACTOR ALPHA-INDUCIBLE CELLULAR PROTEIN CONTAINING LEUCINE ZIPPER DOMAINS (HUNTINGTIN INTERACTING PROTEIN L/HYPL) | 3.09 | 17 % | |
| APRIL: (TNFSF13 OR APRIL OR TALL2 OR ZTNF2) TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13 (A PROLIFERATION-INDUCING LIGAND) (APRIL) | 3.08 | 12 % | |
| CXCL13: (BLC OR BCA1) B LYMPHOCYTE CHEMOATTRACTANT PRECURSOR (CXC CHEMOKINE BLC) (B CELL-ATTRACTING CHEMOKINE 1) (BCA-1) (ANGIE). | 3.07 | 8 % | 63,74 |
| HMOX1: (HMOX1 OR HO1 OR HO) HEME OXYGENASE 1 (HO-1). | 3.07 | 19 % | |
| LCP2: (LCP2) LYMPHOCYTE CYTOSOLIC PROTEIN 2 (SH2 DOMAIN-CONTAINING LEUCOCYTE PROTEIN OF 76 KDA) (SLP-76 TYROSINE PHOSPHOPROTEIN) (SLP76). | 3.03 | 24 % | |
| CD37: (CD37) LEUKOCYTE ANTIGEN CD37. | 3.01 | 10 % | |
| FN1: (FN1 OR FN) FIBRONECTIN PRECURSOR (FN) (COLD-INSOLUBLE GLOBULIN) (CIG). | 2.93 | 7 % | |
| RBP2: (RBP2 OR CRBP2) RETINOL-BINDING PROTEIN II, CELLULAR (CRBP-II). | 2.93 | 43 % | 75 |
| SFA2: (BATF) ATF-LIKE BASIC LEUCINE ZIPPER TRANSCRIPTIONAL FACTOR B-ATF (SF-HT-ACIVATED GENE-2) (SFA-2). | 2.88 | 15 % | |
| GJA1_1: (GJA1) GAP JUNCTION ALPHA-1 PROTEIN (CONNEXIN 43) (CX43) (GAP JUNCTION 43 KDA HEART PROTEIN). | 2.87 | 11 % | 76 |
| GADD45: (GADD45A OR DDIT1 OR GADD45) GROWTH ARREST AND DNA-DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA (DNA-DAMAGE INDUCIBLE TRANSCRIPT 1) | 2.79 | 3 % | 18 |
| ALDH6: (ALDH1A3 OR ALDH6) ALDEHYDE DEHYDROGENASE 6 (RALDH3) RETINALDEHYDE DEHYDROGENASE 3 | 2.76 | 8 % | |
| SOD2: (SOD2 OR SOD-2) SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL PRECURSOR | 2.75 | 12 % | 77 |
| KAI1: (KAI1 OR CD82 OR SAR2) CD82 ANTIGEN (INDUCIBLE MEMBRANE PROTEIN R2) (C33 ANTIGEN) (IA4) (METASTASIS SUPPRESSOR KANGAI 1) (SUPPRESSOR OF TUMORIGENICITY-6). | 2.73 | 9 % | |
| CCL2_RAT: (SCYA2 OR MCP1) SMALL INDUCIBLE CYTOKINE A2 PRECURSOR (MONOCYTE CHEMOTACTIC PROTEIN 1) (MCP-1) (MONOCYTE CHEMOATTRACTANT PROTEIN-1) | 2.67 | 17 % | 78,79 |
| LYSYLOXIDASE: (LOX) PROTEIN-LYSINE 6-OXIDASE PRECURSOR (LYSYL OXIDASE). | 2.67 | 22 % | |
| CD83: (CD83) ANTIGEN PRECURSOR (CELL SURFACE PROTEIN HB15) (B-CELL ACTIVATION PROTEIN). | 2.63 | 7 % | |
| CP: (CP) CERULOPLASMIN PRECURSOR (FERROXIDASE). | 2.62 | 18 % | |
| WNT2: (WNT2 OR IRP OR WNT-2) WNT-2 PROTEIN PRECURSOR (IRP PROTEIN) (INT-1 RELATED PROTEIN). | 2.57 | 11 % | |
| TIMP1: (TIMP1 OR TIMP OR CLGI) METALLOPROTEINASE INHIBITOR 1 PRECURSOR (TIMP-1) (ERYTHROID POTENTIATING ACTIVITY) (EPA) (TISSUE INHIBITOR OF METALLOPROTEINASES | 2.55 | 4 % | 68,80 |
| WNT4: (WNT4 OR WNT-4) WNT-4 PROTEIN PRECURSOR (UNQ426/PRO864). | 2.50 | 29 % | |
| BST1: (BST1 OR BP3 OR BP-3 OR LY65) ADP-RIBOSYL CYCLASE 2 PRECURSOR (CYCLIC ADP-RIBOSE HYDROLASE 2) | 2.48 | 10 % | |
| AHR: (AHR) AH RECEPTOR (ARYL HYDROCARBON RECEPTOR). | 2.45 | 17 % | 81 |
| CYP2D1-CYP2D5_RAT: (CYP2D1 OR CYP2D-1) (CYP2D5 OR CYP2D-5) CYTOCHROME P450 2D1 (CYPIID1) | 2.45 | 23 % | |
| ICAM1: (ICAM1 OR ICAM-1) INTERCELLULAR ADHESION MOLECULE 1 PRECURSOR (ICAM-1) (MAJOR GROUP RHINOVIRUS RECEPTOR) (CD54) (MALA-2). | 2.44 | 15 % | 12,82,83 |
| TGFB1_1: (TGFB1 OR TGFB) TRANSFORMING GROWTH FACTOR BETA 1 PRECURSOR (TGF-BETA 1). | 2.44 | 6 % | 16,74,84-86 |
| COL15A1: (COL15A1) COLLAGEN ALPHA 1(XV) CHAIN PRECURSOR. | 2.42 | 7 % | |
| TF: (TF) SEROTRANSFERRIN PRECURSOR (TRANSFERRIN) (SIDEROPHILIN) (BETA-1-METAL BINDING GLOBULIN) (PRO1400). | 2.40 | 8 % | 87,88 |
| PAP3_RAT: (PAP3 OR REG3G) PANCREATITIS-ASSOCIATED PROTEIN 3 PRECURSOR (REG III-GAMMA). | 2.39 | - % | |
| THY1: (THY1) THY-1 MEMBRANE GLYCOPROTEIN PRECURSOR (THY-1 ANTIGEN) (CDW90) (CD90 ANTIGEN). | 2.39 | 8 % | |
| OSF: (OSTF1 OR SH3D3 OR SH3P2) OSTEOCLAST STIMULATING FACTOR 1 (SH3 DOMAIN PROTEIN 3). | 2.38 | 13 % | |
| CSF1R: (CSF1R OR CSFMR OR FMS) MACROPHAGE COLONY STIMULATING FACTOR I RECEPTOR PRECURSOR (CSF-1-R) | 2.36 | 12 % | |
| BTK: (BTK OR ATK OR AGMX1 OR BPK) TYROSINE-PROTEIN KINASE BTK (BRUTON’S TYROSINE KINASE) | 2.35 | 29 % | |
| CDKN1A: (CDKN1A OR CIP1 OR MDA6 OR CYCLIN-DEPENDENT KINASE INHIBITOR 1 (MELANOMA DIFFERENTIATION ASSOCIATED PROTEIN 6) (MDA-6) | 2.30 | 20 % | |
| PTAFR: (PTAFR OR PAFR) PLATELET ACTIVATING FACTOR RECEPTOR (PAF-R). | 2.29 | 20 % | |
| FN1_EIIIA: (FN1 OR FN) FIBRONECTIN PRECURSOR (FIBRONECTIN EIIIA DOMAIN). | 2.28 | 11 % | |
| BACH1: (BACH1) TRANSCRIPTION REGULATOR PROTEIN BACH1 (BTB AND CNC HOMOLOG 1) (HA2303). | 2.26 | 29 % | |
| ERO1L: (ERO1L) ERO1-LIKE PROTEIN ALPHA PRECURSOR (OXIDOREDUCTIN 1-LALPHA) (ENDOPLASMIC OXIDOREDUCTIN 1-LIKE PROTEIN) | 2.25 | 17 % | |
| IL1R2: (IL1R2 OR IL1RB) INTERLEUKIN-1 RECEPTOR, TYPE II PRECURSOR (IL-1R-2) (IL-1R-BETA). | 2.25 | 19 % | 74,89 |
| CD2: (CD2) T-CELL SURFACE ANTIGEN CD2 PRECURSOR (LEU-5) (LFA-2) (LFA-3 RECEPTOR) (ERYTHROCYTE RECEPTOR) | 2.24 | 16 % | |
| DEC1: (BHLHB2 OR SHARP-2 OR STRA14) STIMULATED BY RETINOIC ACID 14 (BASIC-HELIX-LOOP-HELIX PROTEIN | 2.23 | 15 % | |
| SOX9: (SOX9) TRANSCRIPTION FACTOR SOX-9. | 2.22 | 50 % | |
| TNFSF12: (TNFSF12 OR APO3L OR DR3LG) TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 12 (TNF-RELATED WEAK INDUCER OF APOPTOSIS) (TWEAK) | 2.19 | 225 % | |
| PGH2: (PTGS2 OR COX2) PROSTAGLANDIN G/H SYNTHASE 2 PRECURSOR (CYCLOOXYGENASE-2) (COX-2) (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2) | 2.18 | 26 % | 20,21,90 |
| SOCS3: (SOCS3) STAT INDUCED STAT INHIBITOR-3 (PROTEIN EF-10). (CISH3 OR SOCS-3 OR SOCS3) CYTOKINE INDUCIBLE SH2-CONTAINING PROTEIN 3 | 2.16 | - % | |
| ABME: (APOBEC1) APOLIPOPROTEIN B MRNA EDITING PROTEIN (HEPR) (APOBEC-1). | 2.15 | 16 % | |
| INTEGRINB7: (ITGB7) INTEGRIN BETA-7 PRECURSOR. | 2.15 | 23 % | |
| TLR4: (TLR4) TOLL-LIKE RECEPTOR 4 PRECURSOR (HTOLL). | 2.15 | 19 % | |
| SRC: (SRC OR SRC1) PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (C-SRC). | 2.12 | 13 % | |
| LRP: (MVP OR LRP) MAJOR VAULT PROTEIN (MVP) (LUNG RESISTANCE-RELATED PROTEIN). | 2.09 | 16 % | |
| LAMB3: (LAMB3) LAMININ BETA-3 CHAIN PRECURSOR (LAMININ B1K CHAIN) (KALININ B1 CHAIN). | 2.08 | 14 % | |
| C1S: (C1S) COMPLEMENT C1S COMPONENT PRECURSOR (C1 ESTERASE). | 2.07 | 4 % | 16,18 |
| FMO5: (FMO5) DIMETHYLANILINE MONOOXYGENASE 5 (HEPATIC FLAVIN-CONTAINING MONOOXYGENASE 5) (FMO 5) (DIMETHYLANILINE OXIDASE 5). | 2.06 | 42 % | |
| PDGFRB: (PDGFRB OR PDGFR) BETA PLATELET-DERIVED GROWTH FACTOR RECEPTOR PRECURSOR (PDGF-R-BETA) (CD140B ANTIGEN). | 2.06 | 10 % | 20,21 |
| LAMP2: (LAMP2 OR LAMP-2) LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 2 PRECURSOR (LAMP-2) (LYSOSOMAL MEMBRANE GLYCOPROTEIN-TYPE B) (LGP-B) | 2.05 | 10 % | |
| LOXL1: (LOX OR RRG) PROTEIN-LYSINE OXIDASE HOMOLOG PRECURSOR (LYSYL OXIDASE HOMOLOG) (LYSYL OXIDASE-LIKE PROTEIN) (RAS EXCISION PROTEIN). | 2.05 | 28 % | 22 |
| POLD4: (POLD4 OR POLDS) DNA POLYMERASE DELTA SUBUNIT 4 (DNA POLYMERASE DELTA SUBUNIT P12). | 2.05 | 15 % | |
| ENO2: (ENO2) GAMMA ENOLASE (2-PHOSPHO-D-GLYCERATE HYDRO-LYASE) | 2.04 | 3 % | |
| DCP1: (DCP1 OR DCP OR ACE) ANGIOTENSIN-CONVERTING ENZYME, SOMATIC ISOFORM PRECURSOR (ACE) (DIPEPTIDYL CARBOXYPEPTIDASE I) | 2.00 | 17 % | 91 |
| GLUL: (GLUL OR GLNS) GLUTAMINE SYNTHETASE (GLUTAMATE--AMMONIA LIGASE). | 2.00 | 10 % | |
| PRKCE: (PRKCE OR PKCE) PROTEIN KINASE C, EPSILON TYPE (NPKC-EPSILON). | 2.00 | 19 % | 20,21 |
| ERP5: (CABP1 OR PDIA6 OR 1700015E05RIK) PROTEIN DISULFIDE ISOMERASE A6 PRECURSOR (PROTEIN DISULFIDE ISOMERASE P5). | 0.50 | 6 % | |
| ILF: (ILF1 OR ILF) INTERLEUKIN ENHANCER-BINDING FACTOR 1 (CELLULAR TRANSCRIPTION FACTOR ILF-1). | 0.50 | 16 % | |
| PLC: (PLC-L) PHOSPHOLIPASE C (130KDA-INS (1,4,5)P3 BINDING PROTEIN). | 0.50 | 30 % | |
| POD1: (TCF21 OR POD1 OR COR1) MESODERM-SPECIFIC BASIC-HELIX-LOOP-HELIX PROTEIN. | 0.50 | 13 % | |
| SMAD5: (MADH5 OR SMAD5) MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5 (SMAD 5) (MOTHERS AGAINST DPP HOMOLOG 5) (SMAD5) (HSMAD5) | 0.50 | 20 % | 92 |
| IL12A: (IL12A OR NKSF1) INTERLEUKIN-12 ALPHA CHAIN PRECURSOR (IL-12A) (CYTOTOXIC LYMPHOCYTE MATURATION FACTOR 35 KDA SUBUNIT) (NK CELL STIMULATORY FACTOR CHAIN 1) (NKSF1). | 0.49 | 13 % | 93 |
| RFC5: (RFC5) ACTIVATOR 1 36 KDA SUBUNIT (REPLICATION FACTOR C 36 KDA SUBUNIT) (A1 36 KDA SUBUNIT) (RF-C 36 KDA SUBUNIT) (RFC36). | 0.49 | 9 % | |
| CPT2: (CPT2) CARNITINE O-PALMITOYLTRANSFERASE II, MITOCHONDRIAL PRECURSOR (CPT II). | 0.48 | 12 % | |
| HJ2: (HJ2 JAGGED2) NOTCH LIGAND JAGGED 2. | 0.48 | - % | |
| MMP21-22-23: (MMP-23 OR MMP21/22 OR MIFR-1 OR MIFR OR DJ283E3.2) MMP-23 (MIFR/FEMALYSIN) (DJ283E3.2.1) (MATRIX METALLOPROTEINASE MMP21/22A (MIFR1)) (MATRIX METALLOPROTEINASE 23B) | 0.48 | 9 % | |
| NOP40: (EBNA1BP2 OR EBP2) PROBABLE RRNA PROCESSING PROTEIN EBP2 (EBNA1 BINDING PROTEIN 2) (NUCLEOLAR PROTEIN P40). | 0.48 | 3 % | |
| TM4SF3: (TM4SF3) TUMOR-ASSOCIATED ANTIGEN CO-029 | 0.48 | 7 % | |
| ESR1: (ESR1 OR NR3A1 OR ESR) ESTROGEN RECEPTOR (ER) (ESTRADIOL RECEPTOR). | 0.47 | 1 % | 94,95 |
| HSP40-3: (DNAJB5 OR HSC40) DNAJ HOMOLOG SUBFAMILY B MEMBER 5 (HEAT SHOCK PROTEIN HSP40-3) (HEAT SHOCK PROTEIN COGNATE 40) (HSC40). | 0.47 | 26 % | 96,97 |
| FKBP5: (FKBP5) (54 KDA PROGESTERONE RECEPTOR-ASSOCIATED IMMUNOPHILIN) (FKBP54) (P54) (FF1 ANTIGEN) (HSP90 BINDING IMMUNOPHILIN). | 0.46 | - % | |
| LRRN3: (LRRN3) LEUCINE-RICH REPEAT PROTEIN PRECURSOR (FRAGMENT). | 0.46 | 14 % | |
| ACS-2: (FACL3 OR ACS3 OR LACS3) LONG-CHAIN-FATTY-ACID-COA LIGASE 3 (LONG-CHAIN ACYL-COA SYNTHETASE 3) (LACS 3) | 0.45 | 5 % | |
| IL4R: (IL4R OR IL4RA OR 582J2.1) INTERLEUKIN-4 RECEPTOR ALPHA CHAIN PRECURSOR (IL-4R-ALPHA) (CD124 ANTIGEN) | 0.45 | 7 % | |
| TFRC_MIDDLE: (TFRC) TRANSFERRIN RECEPTOR PROTEIN (TFR1) (CD71 ANTIGEN) | 0.45 | 26 % | |
| THBD: (THBD OR THRM) THROMBOMODULIN PRECURSOR (FETOMODULIN) (TM) | 0.45 | 11 % | |
| VGR2: (KDR OR FLK1) VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 PRECURSOR (VEGFR-2) (KINASE INSERT DOMAIN RECEPTOR) (FLK-1). | 0.45 | - % | 12 |
| FMO1: (FMO1) DIMETHYLANILINE MONOOXYGENASE 1 (FETAL HEPATIC FLAVIN-CONTAINING MONOOXYGENASE 1) (FMO 1) | 0.44 | 13 % | |
| POLD2: (POLD2) DNA POLYMERASE DELTA SMALL SUBUNIT | 0.43 | 11 % | |
| SULT1A1_RAT: (SULT1A1 OR ST1A1) ARYL SULFOTRANSFERASE (PHENOL SULFOTRANSFERASE) (PST-1) (SULFOKINASE) (ARYL SULFOTRANSFERASE IV) (ASTIV) | 0.43 | 3 % | |
| SYK: (SYK) TYROSINE-PROTEIN KINASE SYK (SPLEEN TYROSINE KINASE). | 0.43 | 8 % | |
| ID4: (ID4) DNA-BINDING PROTEIN INHIBITOR ID-4. | 0.41 | 8 % | |
| BCG1: (BCG1 OR MAGED2) BREAST CANCER ASSOCIATED GENE 1 PROTEIN JCL-1 (DJ14O9.2 OR BCG1) DJ14O9.2 (MELANOMA-ASSOCIATED ANTIGEN MAGE LIKE) (JCL-1) | 0.40 | 12 % | |
| IGF1: (IGF-I OR IGF1) INSULIN-LIKE GROWTH FACTOR I PRECURSOR (SOMATOMEDIN). (IGF1 OR IBP1) INSULIN-LIKE GROWTH FACTOR IA PRECURSOR (IGF-IA) | 0.40 | 4 % | |
| FKBP14: (FKBP14 OR FKBP22) FK506 BINDING PROTEIN 14 PRECURSOR (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) | 0.39 | 27 % | |
| FKBP11: (FKBP11 OR FKBP19) FK506 BINDING PROTEIN 11 PRECURSOR (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) | 0.37 | 8 % | |
| FKBP4: (FKBP4) P59 PROTEIN (HSP BINDING IMMUNOPHILIN) (HBI) (ROTAMASE) (52 KDA FK506 BINDING PROTEIN) (P52) (FKBP59) (HSP56). | 0.36 | 6 % | |
| MT1_RAT: (MT1) METALLOTHIONEIN-I (MT-I). | 0.32 | 4 % | |
| TRK-B: (NTRK2 OR TRKB) BDNF/NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (TRKB TYROSINE KINASE) | 0.31 | 23 % | 20,21,98 |
| UMAT: (ABCB6 OR MTABC OR MTABC3 OR ABCB7 OR ABC7) ABC TRANSPORTER UMAT (MT-ABC TRANSPORTER) (MITOCHONDRIAL ABC TRANSPORTER 3) ATP-BINDING CASSETTE | 0.28 | 34 % | |
| WNT5A: (WNT5A OR WNT-5A) WNT-5A PROTEIN PRECURSOR. | 0.26 | 24 % | 59 |
| EGFR-LONG: (EGFR OR ERBB1) EPIDERMAL GROWTH FACTOR RECEPTOR PRECURSOR (RECEPTOR PROTEIN-TYROSINE KINASE ERBB-1). | 0.24 | 38 % | 99,100 |
| MT2_RAT: (MT2) METALLOTHIONEIN-II (MT-II). | 0.24 | 6 % | |
| FKHL16: (FOXM1 OR FKHL16 OR HFH11 OR WIN OR MPP2) FORKHEAD PROTEIN M1 (FORKHEAD-RELATED PROTEIN FKHL16) (HEPATOCYTE NUCLEAR FACTOR 3 FORKHEAD HOMOLOG 11) | 0.23 | - % | |
| GSTM1_RAT: (GSTM1 OR GST1) GLUTATHIONE S-TRANSFERASE MU 1 (GSTM1-1) (HB SUBUNIT 4) (GTH4) (GSTM1A-1A) (GSTM1B-1B) (GST CLASS-MU). | 0.23 | 7 % | 101 |
| NGFR: (NGFR OR TNFRSF16) LOW-AFFINITY NERVE GROWTH FACTOR RECEPTOR PRECURSOR (NGF RECEPTOR) (LOW AFFINITY NEUROTROPHIN RECEPTOR P75NTR). | 0.19 | 34 % | |
| FUT2: (FUT2 OR SEC2) GALACTOSIDE 2-ALPHA-L-FUCOSYLTRANSFERASE 2 (GDP-L-FUCOSE:BETA-D-GALACTOSIDE 2-ALPHA-L-FUCOSYLTRANSFERASE 2) | 0.15 | 8 % | |
| GLI1: (GLI OR GLI1) ZINC FINGER PROTEIN GLI1 (GLIOMA-ASSOCIATED ONCOGENE) (ONCOGENE GLI). | 0.14 | 20 % | |
| LEFTY1-LEFTY2_RAT: (EBAF OR TGFB4 OR LEFTA OR LEFTYA) TRANSFORMING GROWTH FACTOR BETA 4 PRECURSOR (TGF-BETA 4) (ENDOMETRIAL BLEEDING-ASSOCIATED FACTOR) | 0.14 | 51 % | 102 |
| HSD11B2: (HSD11B2 OR HSD11K) CORTICOSTEROID 11-BETA-DEHYDROGENASE, ISOZYME 2 (11-DH2) | 0.05 | 10 % | 103 |
| ORM1: (ORM1 OR AGP1) ALPHA-1-ACID GLYCOPROTEIN 1 PRECURSOR (AGP 1) (OROSOMUCOID 1) (OMD 1). | 0.03 | 23 % |
a
Percent standard deviation (otherwise known as the relative standard deviation RSD) is obtained by multiplying the standard deviation by 100 and dividing this product by the average