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. 1964 Nov 7;91(19):1006–1010.

Studies on the Inhibition of Intestinal Absorption of Radioactive Strontium

III. The Effect of Administration of Sodium Alginate in Food and in Drinking Water

Deirdre Waldron-Edward, T M Paul, Stanley C Skoryna
PMCID: PMC1928066  PMID: 14222668

Abstract

A method is reported which permits selective suppression of absorption of radioactive strontium from ingested food material, permitting calcium to be available to the body. Studies were carried out by measuring bone uptake of Sr89 and Ca45 when various amounts of sodium alginate were fed with the diet. Long-term studies were made in which two different levels of radioactivity were used, to determine the pattern of Sr89 deposition with continuous intake of binding agent. It was found that administration of sodium alginate as a jelly overcomes the problem of constipation and effectively reduces Sr89 uptake, up to 83%. This fact represents a significant finding with respect to the use of the compound in human subjects. Addition of sodium alginate to drinking water is effective with low levels of Sr89 intake.

This naturally occurring water-soluble macromolecular substance possesses several advantages in use for the suppression of absorption of radioactive strontium when compared with synthetic ion exchange resins: there is no disturbance of electrolyte balance; efficiency is not reduced by treatment over a prolonged period of time; and finally, the product is palatable.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COMAR C. L., NOLD M. M., WASSERMAN R. H. Strontium-calcium discrimination factors in the rat. Proc Soc Exp Biol Med. 1956 Aug-Sep;92(4):859–863. doi: 10.3181/00379727-92-22636. [DOI] [PubMed] [Google Scholar]
  2. MacDONALD N. S., NUSBAUM R. E., EZMIRLIAN F., BARBERA R. C., ALEXANDER G. V., SPAIN P., ROUNDS D. E. Gastrointestinal absorption of ions. I. Agents diminishing absorption of strontium. J Pharmacol Exp Ther. 1952 Mar;104(3):348–353. [PubMed] [Google Scholar]
  3. McCHESNEY E. W., McAULIFF J. P. Effects of some ion exchange resins on the mineral metabolism of rats. Am J Physiol. 1950 Feb;160(2):264–276. doi: 10.1152/ajplegacy.1950.160.2.264. [DOI] [PubMed] [Google Scholar]
  4. SKORYNA S. C., PAUL T. M., EDWARD D. W. STUDIES ON INHIBITION OF INTESTINAL ABSORPTION OF RADIOACTIVE STRONTIUM. I. PREVENTION OF ABSORPTION FROM LIGATED INTESTINAL SEGMENTS. Can Med Assoc J. 1964 Aug 8;91:285–288. [PMC free article] [PubMed] [Google Scholar]

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