FIGURE 7.

Mean first-opening latencies for single and multiple IP₃R after different steps of at various [Ca²⁺]. (A and B) The mean first-opening latency of an individual IP₃R channel (A) as a function of with [Ca²⁺] = 0.1 μM, and the corresponding latencies for the first opening of any channel among a population of 50 IP₃R channels (i.e., the predicted puff latency) (B). (C and D) Corresponding dependence of mean single-channel first-opening latency (C) and puff latency (D) for a cluster of 50 channels as a function of [Ca²⁺] for (stars) and (squares).