Table 5.

Functional clustering of 147 fly orthologs of genes showing significant differences in expression between honey bee species, based on Gene Ontology-defined molecular functions

Cluster	GO ID	GO category	Level	No. of genes	Fly orthologs	p value
1	GO:0008233	peptidase activity	4	6	Rpn2, CG32130, CG4998, CG5798, east, CG4678	3.828e-05
2	GO:0005488	binding	2	15	CG3244, CG7966, CG3104, CG30387, Tsp96F, dsd, Hop, CG5001, CG6946, Rsf1, RpL6, Ef1γ, Rpb8, e, CG8745	0.007796
3	GO:0008092	cytoskeletal protein binding	4	6	Tctp, CLIP-190, coro, CG32030, chic, bif	1.823e-07
4	GO:0005215	transporter activity	2	6	CG32250, Tsp5D, PebIII, CG1358, CG6783, Cralbp	0.007066
5	GO:0008270	zinc ion binding	1	7	CG32486, Pax, Sodh-2, Nep2, S2P, Ance, Psa	1.021e-07
6	GO:0016462	pyrophosphatase activity	6	7	RhoBTB, Hsp83, Hsc70-4, Mnn1, Atet, CG33310, CG1271	1.276e-08
7	GO:0005488	binding	2	21	Tctp, CLIP-190, coro, CG32030, chic, bif, fru, CG3726, gro, CG32486, Pax, Sodh-2, Nep2, S2P, Ance, Psa, Cad87A, CG11105, BM-40-SPARC, Tsf1, CG4349	5.259e-05
8	GO:0003824	catalytic activity	2	33	Rpn2, CG32130, CG4998, CG5798, east, CG4678, wun, CG9265, Sulf1, pyd3, PGRP-SC2, Sirt2, α-Man-IIb, CG11257, CG9360, CG6439, antdh, CG10962, CG10638, b, CG6028, Mdh, ACXD, Gycβ100Bb100B, Pglym78, FKBP59, CG10903, CG10527, Pcmt, CG10178, Ugt86Dd, CG5037, Dat	5.480e-11
9	GO:0016740	transferase activity	3	7	CG10903, CG10527, Pcmt, CG10178, Ugt86Dd, CG5037, Dat	4.211e-06
10	GO:0016787	hydrolase activity	3	13	Rpn2, CG32130, CG4998, CG5798, east, CG4678, wun, CG9265, Sulf1, pyd3, PGRP-SC2, Sirt2, α-Man-IIb	1.016e-07
11	GO:0003676	nucleic acid binding	3	5	CG6946, Rsf1, RpL6, Ef1γ, Rpb8	0.000773
12	GO:0043167	ion binding	3	12	CG32486, Pax, Sodh-2, Nep2, S2P, Ance, Psa, Cad87A, CG11105, BM-40-SPARC, Tsf1, CG4349	1.837e-12
13	GO:0005515	protein binding	3	9	Tctp, CLIP-190, coro, CG32030, chic, bif, fru, CG3726, gro	0.000444
14	GO:0016491	oxidoreductase activity	3	6	CG11257, CG9360, CG6439, antdh, CG10962, CG10638	3.828e-05

See Table 4 legend for details