Table 4.

Univariate and multivariate Cox analyses in the Stiftung Tumorbank Basel data set (n = 317)

Factor	Univariate metastasis-free survival		Multivariate metastasis-free survival
	Hazard ratio (95% confidence interval)	P value	Hazard ratio (95% confidence interval)	P value
E2F1 (>p30 versus ≤ p30)	4.27 (1.83–9.96)	0.001	2.95 (1.10–7.93)	0.032
Grade (3 versus 1 + 2)	2.03 (1.17–3.51)	0.011	1.56 (0.77–3.14)	0.213
Estrogen receptor status (positive versus negative)	0.64 (0.37–1.12)	0.120	1.21 (0.56–2.61)	0.625
ERBB2 status (positive versus negative)	1.69 (0.98–2.92)	0.058	1.41 (0.70–2.81)	0.335
pN (>3 nodes versus ≤ 3 nodes)	3.14 (1.76–5.61)	<0.001	2.36 (1.14–4.88)	0.021
Size (>2 cm versus ≤ 2 cm)	1.95 (1.05–3.62)	0.036	1.19 (0.58–2.43)	0.641
Age (≤ 40 years versus >40 years)	0.30 (0.15–0.59)	0.001	0.59 (0.24–1.43)	0.246
Chemotherapy	2.65 (1.54–4.55)	<0.001	1.27 (0.45–3.59)	0.654
Hormone therapy	0.50 (0.28–0.88)	0.017	0.76 (0.27–2.17)	0.605
70-gene signature (poor versus good prognosis)	Not available	Not available	Not available	Not available