Table 5.

Univariate and multivariate Cox analyses in The Netherlands Cancer Institute data set (n = 295)

Factor	Univariate metastasis-free survival		Multivariate metastasis-free survivala
	Hazard ratio (95% confidence interval)	P value	With 70-gene signature		Without 70-gene signature
			Hazard ratio (95% confidence interval)	P value	Hazard ratio (95% confidence interval)	P value
E2F1 (>p30 versus ≤ p30)	5.09 (2.65–9.78)	<0.001	3.76 (1.90–7.45)	<0.001	2.47 (1.20–5.10)	0.014
Grade (3 versus 1 + 2)	2.38 (1.60–3.52)	<0.001	1.28 (0.82–2.00)	0.277	1.02 (0.65–1.60)	0.931
Estrogen receptor status (positive versus negative)	0.54 (0.36–0.83)	0.005	0.99 (0.61–1.59)	0.956	1.11 (0.70–1.78)	0.658
ERBB2 status (positive versus negative)	1.61 (1.01–2.57)	0.045	1.35 (0.82–2.21)	0.234	1.28 (0.78–2.09)	0.330
pN (>3 nodes versus ≤ 3 nodes)	2.20 (1.37–3.53)	0.001	2.35(1.32–4.21)	0.004	2.69 (1.47–4.91)	0.001
Size (>2 cm versus ≤ 2 cm)	2.08 (1.39–3.10)	<0.001	1.70 (1.12–2.58)	0.013	1.73 (1.14–2.62)	0.010
Age (≤ 40 years versus >40 years)	0.50 (0.33–0.75)	0.001	0.59 (0.38–0.89)	0.013	0.67 (0.43–1.02)	0.063
Chemotherapy	0.79 (0.52–1.19)	0.254	0.61 (0.38–1.00)	0.051	0.55 (0.33–0.91)	0.020
Hormone therapy	0.58 (0.28–1.19)	0.139	0.60 (0.28–1.27)	0.181	0.58 (0.27–1.23)	0.157
70-gene signature (poor versus good prognosis)	4.55 (2.67–7.77)	<0.001	Not included	Not included	2.78 (1.49–5.21)	0.001

^aMultivariate metastasis-free survival calculated once with and once without the 70-gene signature.