Table 7.
Estimation of the subcellular proteomes of eight eukaryotic organisms
| Yeast (S. cerevisiae) | Worm (C. elegans) | Fruitfly (D. melano) | Mosquito (A. gambiae) | Zebrafish (D. rerio) | Chicken (G. gallus) | Mouse (M. musculus) | Human (H. sapiens) | Range | |
| Proteome | 5,799 | 22,400 | 13,649 | 15,145 | 13,803 | 5,394 | 33,043 | 38,149 | |
| GO annotated | 5,486 | 12,357 | 9,997 | 8,847 | 10,106 | 4,363 | 23,744 | 24,638 | |
| % ngLOC coverage | 97.48 | 94.92 | 96.73 | 97.94 | 98.64 | 9,9.82 | 94.79 | 94.52 | 94.79-99.82 |
| Proteome estimated | 5,653 | 21,262 | 13,203 | 14,833 | 13,616 | 5,384 | 31,320 | 36,059 | |
| % CYT | 15.22 | 14.80 | 12.74 | 14.43 | 15.01 | 13.66 | 13.44 | 14.14 | 12.74-15.22 |
| % CSK | 1.07 | 1.19 | 1.05 | 1.11 | 1.31 | 1.24 | 1.50 | 1.48 | 1.05-1.50 |
| % END | 2.71 | 3.47 | 2.85 | 3.25 | 3.34 | 2.53 | 2.99 | 3.04 | 2.53-3.47 |
| % EXC | 8.88 | 12.60 | 12.26 | 14.28 | 9.91 | 12.65 | 11.52 | 11.71 | 8.88-14.28 |
| % GOL | 1.48 | 1.31 | 1.40 | 1.07 | 1.68 | 1.47 | 1.52 | 1.56 | 1.07-1.68 |
| % LYS | 0.11 | 0.58 | 0.55 | 0.53 | 0.65 | 0.44 | 0.59 | 0.67 | 0.11-0.67 |
| % MIT | 9.55 | 5.84 | 4.86 | 5.52 | 4.72 | 4.16 | 4.24 | 4.80 | 4.16-9.55 |
| % NUC | 33.53 | 29.75 | 37.38 | 29.50 | 30.31 | 28.24 | 27.35 | 28.38 | 27.35-37.38 |
| % PLA | 16.19 | 24.41 | 20.06 | 21.36 | 21.66 | 22.78 | 27.18 | 24.08 | 16.19-27.18 |
| % POX | 0.54 | 0.66 | 0.42 | 0.48 | 0.51 | 0.25 | 0.44 | 0.46 | 0.25-0.66 |
| % Single-localized | 89.29 | 94.60 | 93.59 | 91.53 | 89.11 | 87.42 | 90.77 | 90.32 | |
| % Multi-localized | 10.71 | 5.40 | 6.41 | 8.47 | 10.89 | 12.58 | 9.23 | 9.68 | |
| % CYT-NUC | 6.49 | 2.36 | 2.76 | 3.44 | 5.40 | 6.27 | 4.51 | 4.74 | |
This chart presents the location-wise percentages of the proteome predicted to localize into one organelle. (For example, 9.55% of the yeast proteome is localized to the mitochrondria only.) These percentages sum to the total size of the proteome estimated to be single-localized. We also present the estimated percentage of the proteome that is localized to multiple organelles. The percentage of the proteome estimated to localize to both the cytoplasm and nucleus is also displayed. The coverage is determined with a confidence score (CS) threshold of 15. Multi-localized sequences are determined with a multi-localized confidence score (MLCS) threshold of 60. CSK, cytoskeleton; CYT, cytoplasm; END, endoplasmic reticulum; EXC, extracellular; GO, Gene Ontology; GOL, golgi; LYS, lysosome; MIT, mitochondria; NUC, nucleus; PLA, plasma membrane; POX, perixosome.