Figure 4.

Association between BRPR scores and detectable sites. For each given percent of detectable transcription factor binding sites (TFBSs), the combination of aligned genomes with the highest base regulatory potential rate (BRPR) value will yield the smaller conserved region (for phylogenetic footprinting algorithm searches). The full list of genome combinations and their BRPR values are given in Additional data file 1. The blue line presents the association between percentage of human TFBSs located in conserved regions in a combination of genomes with this BRPR value among all possible genome combinations in this study (see text for detailed description). The grey line plot is similar after the opossum genome is omitted (see text). BRPR, base regulatory potential rate.