Table 4.

Human-mouse TFBS conservation dependency on transcription factor identity

Factor	Motif		Human versus mouse
	IC	Length	Detectable	% conserved	p value	Over/under
HMG	8.43	9	7	100.00%	0.1029
CREB	11.52	8	17	94.12%	0.0257	Over
c-Myb	14.15	11	11	90.91%	0.1186
NF-AT1	N/A	N/A	10	90.00%	0.1494
IPF1	N/A	N/A	9	88.89%	0.1862
p50	15.63	11	8	87.50%	0.2292
NF-κB	13.34	10	14	85.71%	0.1425
AhR	8.62	6	7	85.71%	0.2775
GR	7.06	6	7	85.71%	0.2775
E2F-1	10.17	8	12	83.33%	0.1982
AP-1	9.44	7	34	82.35%	0.0686
HIF-1	11.00	11	11	81.82%	0.2286
MITF	N/A	N/A	11	81.82%	0.2286
ATF-2	N/A	N/A	9	77.78%	0.2864
USF1	10.37	6	9	77.78%	0.2864
C/EBPα	11.12	9	22	77.27%	0.1745
p53	25.74	18	22	72.73%	0.1897
E2F	13.84	8	11	72.73%	0.2631
c-Ets-1	N/A	N/A	7	71.43%	0.3193
HNF-1α	N/A	N/A	7	71.43%	0.3193
Egr-1	13.12	9	12	66.67%	0.2184
POU1F1a	7.57	5	12	66.67%	0.2184
Sp1	9.22	8	115	66.09%	0.0250	Under
HNF-1α-A	13.66	10	11	63.64%	0.2010
GATA-1	5.57	4	14	57.14%	0.1007
TCF-4	12.54	7	7	57.14%	0.2032
EBF	21.10	15	8	50.00%	0.1120
AP-2αA	N/A	N/A	23	47.83%	0.0073	Under
ER-α	N/A	N/A	11	45.45%	0.0405	Under
Crx	11.60	10	7	42.86%	0.0772
Gfi1	7.60	4	17	35.29%	0.0012	Under*
AR	N/A	N/A	7	14.29%	0.0022	Under

Factors with more than seven sites detectable between the two species are shown. The p values given pertain to the observed percentage of conserved sites, and were determined using the Fisher's exact test. Over/under, specifies over-conservation or under-conservation of the sites of the corresponding transcription factor (by Fisher's exact test) at the 5% significance level; *Significant under-representation after p value correction (using Bonferroni). Detectable, total number of human transcription factor binding sites located in promoters of mouse orthologous genes; % conserved, percentage of detectable sites that are in conserved regions; IC, information content (total); Length, length of the motif; N/A, there is no available position-specific score matrix model for this transcription factor; TFBS, transcription factor binding site.