Table 6.
Human-mouse TFBS conservation dependency on the GO category of the downstream regulated gene
| GO category | Number of genes | Upstream coverage | Detectable TFBSs | % TFBS detected | p value | Over/under |
| Transcription regulator activity | 34 | 37.65% | 128 | 83.59% | 6.63 × 10-4 | Over* |
| Cell-cell signaling | 44 | 26.00% | 141 | 82.27% | 1.27 × 10-3 | Over* |
| Development | 55 | 35.19% | 157 | 81.53% | 1.41 × 10-3 | Over* |
| Nucleotide binding | 42 | 23.31% | 137 | 79.56% | 1.04 × 10-2 | Over |
| Response to biotic stimulus | 81 | 22.67% | 273 | 79.49% | 5.62 × 10-4 | Over* |
| Response to external stimulus | 65 | 23.49% | 209 | 79.43% | 2.56 × 10-3 | Over |
| Response to stress | 91 | 23.78% | 316 | 79.11% | 3.50 × 10-4 | Over* |
| Physiologic process | 154 | 23.59% | 526 | 78.90% | 1.37 × 10-6 | Over* |
| Cell proliferation | 53 | 29.13% | 209 | 78.47% | 6.00 × 10-3 | Over |
| Receptor binding | 65 | 24.36% | 246 | 77.24% | 9.74 × 10-3 | Over |
| Receptor activity | 42 | 24.55% | 114 | 77.19% | 4.29 × 10-2 | Over |
| Mitochondrion organization and biogenesis | 100 | 25.26% | 266 | 77.07% | 8.93 × 10-3 | Over |
| Transcription | 67 | 35.72% | 223 | 76.68% | 1.82 × 10-2 | Over |
| Extracellular region | 56 | 21.66% | 217 | 76.04% | 2.73 × 10-2 | Over |
| Protein binding | 142 | 26.43% | 464 | 75.86% | 4.75 × 10-3 | Over |
| Extracellular space | 54 | 23.08% | 232 | 75.86% | 2.70 × 10-2 | Over |
| Regulation of biologic process | 155 | 29.96% | 562 | 75.27% | 4.97 × 10-3 | Over |
| Cytoplasm | 45 | 22.87% | 136 | 74.26% | 7.17 × 10-2 | |
| Plasma membrane | 57 | 20.12% | 143 | 74.13% | 7.10 × 10-2 | |
| Transcription factor activity | 42 | 36.92% | 137 | 73.72% | 7.62 × 10-2 | |
| Nucleus | 92 | 31.28% | 332 | 73.49% | 5.00 × 10-2 | |
| Cell death | 48 | 21.97% | 189 | 73.02% | 6.95 × 10-2 | |
| Protein metabolism | 49 | 19.65% | 147 | 72.79% | 7.83 × 10-2 | |
| Biologic process | 35 | 21.69% | 100 | 72.00% | 9.24 × 10-2 | |
| Signal transduction | 116 | 23.96% | 398 | 71.86% | 5.33 × 10-2 | |
| Cell cycle | 41 | 28.45% | 182 | 70.88% | 6.34 × 10-2 | |
| Cell | 118 | 21.23% | 351 | 69.23% | 1.68 × 10-2 | Under |
| Binding | 90 | 24.17% | 297 | 68.69% | 1.58 × 10-2 | Under |
| Transport | 39 | 24.11% | 146 | 67.81% | 3.30 × 10-2 | Under |
| Catalytic activity | 40 | 19.68% | 99 | 61.62% | 4.63 × 10-3 | Under |
| Transporter activity | 35 | 25.00% | 123 | 60.98% | 1.20 × 10-3 | Under* |
The top 31 Gene Ontology (GO) categories in terms of gene numbers in the dataset are shown. The p values given represent the significance (uncorrected) of the observed percentage of conserved (detected) sites, as determined using the Fisher's exact test. Over/under, specifies over-conservation or under-conservation of the sites of the corresponding GO category (by Fisher's exact test) at the 5% significance level. *Statistical over-representation or under-representation after p value correction (using Bonferroni). TFBS, transcription factor binding site.