Table 7.

Human-opossum TFBS conservation dependency on the GO category of the downstream regulated gene

GO category	Number of genes	Upstream Coverage	Detectable TFBSs	% TFBS Detected	p value	Over/under
Receptor binding	51	6.49%	180	55.56%	5.80 × 10-6	Over*
Cell-cell signaling	35	6.37%	120	51.67%	3.67 × 10-3	Over
Physiologic process	122	5.63%	415	49.40%	1.51 × 10-6	Over*
Response to external stimulus	54	5.60%	168	48.81%	6.12 × 10-3	Over
Transcription regulator activity	32	10.15%	122	47.54%	2.47 × 10-2	Over
Extracellular space	43	4.08%	175	47.43%	1.23 × 10-2	Over
Response to biotic stimulus	60	5.29%	209	47.37%	7.82 × 10-3	Over
Transcription	61	10.52%	208	45.67%	2.13 × 10-2	Over
Transcription factor activity	40	9.80%	133	45.11%	4.65 × 10-2	Over
Development	47	9.48%	120	45.00%	5.25 × 10-2
Signal transduction	86	5.72%	293	44.71%	1.95 × 10-2	Over
Response to stress	74	6.23%	268	44.03%	3.18 × 10-2	Over
Regulation of biologic process	134	8.49%	490	43.06%	2.59 × 10-2	Over
Cell	82	6.11%	241	40.66%	5.96 × 10-2
Nucleus	81	10.05%	305	40.66%	5.52 × 10-2
Extracellular region	44	6.17%	160	40.63%	6.95 × 10-2
Cell proliferation	49	7.63%	196	40.31%	6.26 × 10-2
Mitochondrion organization and biogenesis	77	6.90%	213	39.44%	5.29 × 10-2
Cytoplasm	34	6.07%	97	39.18%	7.95 × 10-2
Cell death	41	6.77%	164	37.80%	4.34 × 10-2	Under
Protein binding	122	7.01%	419	35.80%	4.81 × 10-4	Under*
Cell cycle	39	7.67%	176	35.23%	1.35 × 10-2	Under
Nucleotide binding	32	5.82%	112	31.25%	5.81 × 10-3	Under
Protein complex	28	5.90%	84	29.76%	7.37 × 10-3	Under
DNA binding	27	10.05%	74	29.73%	1.08 × 10-2	Under
Binding	71	6.77%	240	29.58%	5.58 × 10-6	Under*
Receptor activity	31	6.53%	88	29.55%	5.67 × 10-3	Under
Plasma membrane	37	4.78%	91	28.57%	3.00 × 10-3	Under
Protein metabolism	41	6.27%	131	25.95%	3.75 × 10-5	Under*
Transporter activity	31	6.28%	91	23.08%	6.74 × 10-5	Under*
Transport	32	5.53%	102	20.59%	1.85 × 10-6	Under*

See Table 6 footnote for details.