Table 3.

Effect of daidzin and its structural analogs on hamster liver MAO activity

Compounds	MAO inhibition IC50, μM	Ethanol intake* suppression, %
Deczein	25	84
Hepzein	9	69†
Hexzein	10	70†
Daidzin	n.i.	62†
Daidzein	22	32†
Puerarin	n.i.	0†
Dicarboxymethyl-daidzein	n.i.	0

Hamster liver mitochondrial membrane was used as a source of MAO. MAO activity was assayed as described in Materials and Methods by using 10 μM DA as the substrate. n.i, no inhibition up to 30 μM. 

^*Ethanol intake-suppresssive activity was measured as described in ref. 1. Dose = 70 meq per hamster per day, i.p. 

^†Data taken from ref. 12.