Table 2.

Thiazolidinedione and RXR-specific retinoids stimulate differentiation of PPARγ-expressing fibroblasts

Cell line	% lipid containing cells
	No activator	+PIO	+LG268	+PIO+LG268
NIH vector	0	0	0	<1
NIH PPARγ	2-5	55-75	50-65	>90

NIH vector and NIH PPARγ cells were treated at confluence for 7 days with no activator, 1 μM pioglitazone alone, 50 nM LG268 alone, or 5 μM thiazolidinedione and 50 nM LG268 as indicated. After an additional 4 days of culture cells were fixed and stained with oil red O. Data are presented as the range of morphologically recognizable differentiation observed for each cell line over three separate experiments.