TNF receptor 1/TNF receptor 2 double knock out mice are not protected from titanium particle-induced osteolysis. Osteolysis was measured in the entire parietal bones (A) and in the suture regions (B). Data are presented as box plots showing the 10th, 25th, 50th, 75th, and 90th, percentiles. In A, n = 12 for the first and second groups and n = 24–26 for the third, fourth, fifth, and sixth groups. In B, n = 6 for the first and second groups and n = 12–13 for the third, fourth, fifth, and sixth groups.