Table 2.
D1 receptor binding in juvenile rats (PD 42) after three weeks of daily administration of risperidone
| Brain region | Controls | RSP(0.3 mg/kg) | Juvenile Rats RSP(1.0 mg/kg) | RSP(3.0 mg/kg) | Adult Rats RSP(3.0 mg/kg) |
|---|---|---|---|---|---|
| Cerebral cortex | |||||
| Medical-prefrontal | 31.2 ± 1.7 (100) | 29.3 ± 1.6 (94) | 32.5 ± 1.7 (104) | 31.4 ± 1.0 (101) | (85) |
| Dorsolateral | 22.7 ± 1.0 (100) | 20.6 ± 1.2 (91) | 21.1 ± 1.1 (93) | 22.6 ± 0.4 (100) | (120) |
| Nucleus accumbens | 177 ± 11.0 (100) | 182 ± 12.5 (103) | 236 ± 20.9 (133)* | 290 ± 12.7 (164)* | (103) |
| Caudate-putamen | |||||
| Medial | 168 ± 16.8 (100) | 190 ± 19.0 (113) | 261 ± 19.1 (155)* | 295 ± 18.6 (176)* | (99) |
| Lateral | 187 ± 16.9 (100) | 206 ± 16.2 (110) | 281 ± 19.0 (150)* | 333 ± 13.8 (178)* | (103) |
| Hippocampus | 19.7 ± 1.5 (100) | 16.8 ± 1.7 (85) | 18.3 ± 0.8 (93) | 19.6 ± 0.7 (99) | (111) |
Data are mean ± SEM values for binding (fmol/mg tissue, [% of control]), determined by quantitative autoradiography following daily i.p. injection of vehicle or risperidone (RSP) for 3 weeks, with significant differences from controls indicated in bold ([*] p<0.05, N=6 rats/group). Data (% of control) for RSP (3 mg/kg/d) in adult animals were reported previously (Tarazi et al., 2001) and are shown for comparison.