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. Author manuscript; available in PMC: 2007 Jul 23.
Published in final edited form as: Hum Mol Genet. 2006 May 8;15(12):2003–2014. doi: 10.1093/hmg/ddl124

Figure 5. Model for role of ID proteins in regulating neuronal maturational differentiation.

Figure 5

In immature neurons with high expression of ID proteins, heterodimers of bHLH-ID prevent DNA binding and expression of differentiation associated genes like NEUROD1. Upon neuronal maturation, elevated levels of MeCP2 repress the expression of ID genes, resulting in functional bHLH-bHLH dimers that can bind to E-box DNA sequences and activate transcription of differentiation associated genes such as NEUROD1, ASCL1 and NEUROG1.