Table 3.

Clinical and neuroimaging data from the index and any recurrent central nervous system event in 19 patients from the East London cohort who had a central nervous system event during a prospective study (Table 2, Kirkham et al., 2001a)

	First CNS event after screening (TCD and sleep study)				Second CNS event
Patient	Age	Context	Clinical	Type of event	Age	Context	Clinical	Neuroimaging
1	8	Facial infection	R partial seizure prolonged, coma	Stroke	–			Bilateral borderzone infarcts (Figure 3)
2	9	Pain	Headache, dizziness, confusion	Stroke	12		Transient parathesia	Normal
3	11	Pain	Headache, diplopla, dizziness, VIth nerve palsy	TIA	12	Pain	Organic psychosis with hallucinations	Normal
4	9	Pain	Dizzy	TIA	.			Normal
5	0.1		Twitching right arm, blood stained CSF, ventricular haemorhage, hydrocephalus, ventriculoperitoneal shunt, seizures	TIA	9		Collapse, drooling, unable to see, unresponsive, seizures, incontinent, brain death	Venous sinus thrombosis, cerebral oedema (Sébire et al. 2005)
6	9	Severe OSA	Left hemiparesis	Stroke	11		R facial palsy	Atrophy left parietooccipital
7	10	Pain	Dizzy, headache, mild diplegia	Stroke	11		R hemiparesis	Increase in white matter abnormality
8	2	URTI	Floppy, unable to hold head, aphasic few hours, looked vacant, staggering to left	Stroke	7		R hemiparesis	New infarct middle cerebral artery territory
9	12	Pain	Severe headache, vomiting, neck stiffness, hypertension	Stroke	.			Haemorrhagic infarct
10	16	Aplastic	Dizzy, left paraesthesiae, left weakness, collapsed, shaking upper limbs, fluctuating conscious level	Stroke	.			New infarct basal ganglia (Figure 4)
11	15	Pain	Diplopia; divergent squint	TIA	.			‘Covert’ infarct, no change
12	3		Headaches, right sided weakness	TIA	6		Drags right foot	Increase in white matter abnormality
13	1.5		Not using right arm	TIA	6		R weakness, severe behaviour problems	‘Covert’ infarct, no change
14	15		Intermittent difficulty writing right hand	TIA	.			‘Covert’ infarct, no change
15	10		Squint	TIA	10		Intermittent blurred visison, 2*episodes of falling, unsteady afterwards, headache	Normal
16	10		Headache, blurring vision L eye	Seizure	13		Dizzy, not moving arm, headache, EEG-bursts slow both temporal R>L, discharges R posterior temporal	Normal
17	1.5	Diarrhoea, dehydration, femoral thrombosis	Extensor posturing, GCS 4	Seizure	3		Scratches table, wall or just blank, sleeps after	New ‘covert’ infarct
18	13	Pain	Headache, Unconscious, twitching arms, eyes deviated L, brief absences, visual disturbance	Seizure	13		Seizure lasting 7 minutes	New ‘covert’ infarct
19	4	Pain	Headache, uprolling eyes lasted few secs, flickering eyelids, afebrile. Talking to nurse-bizarre facial movements, uprolling eyes, twitching fingers, EEG normal	Seizure	4		Episodes shaking down right side*4 at night-wakes him	New ‘covert’ infarct

OSA, Obstructive sleep apnoea; TIA, Transient ischaemic attack; EEG, Electroencephalogram; R, Right; L, Left; GCS, Glasgow Coma Score.