TABLE 2—
No.a | % Having Any Detectable Levelb | Adjusted OR (95% CI)c | |
Total NNAL | |||
Protected workers (reference) | 31 | 45.2 | 1.00 |
Exposed Workers | 50 | 76.0 | 5.66 (1.67, 19.14)* |
Total nicotine | |||
Protected workers (reference) | 32 | 9.4 | 1.00 |
Exposed workers | 52 | 90.4 | 109.01 (20.42, 581.77)** |
Total cotinine | |||
Protected workers (reference) | 32 | 18.8 | 1.00 |
Exposed workers | 52 | 92.3 | 95.21 (15.97, 567.61)** |
Notes. NNAL = 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; OR = odds ratio; CI = confidence interval.
aTotal NNAL (pmol/mL) could not be determined in 3 participants’ urine samples.
bDetection limits: cotinine, 2 ng/mL; nicotine, 2 ng/mL; NNAL, 0.007–0.01 pmol/mL. In nonsmokers, the half-life for nicotine is 2 hours,56 for cotinine is 16.9 hours,56 and for NNAL is unknown. In smokers, the half-life for nicotine is 2.6 hours,56 for cotinine is 17.5 hours,56 and for NNAL is 3–4 days for the distribution phase and 40–45 days for the elimination phase.51
cOdds ratios were based on logistic regression and adjusted for participant age, gender, and minutes exposed to secondhand smoke outside the workplace in the past week.
* P < .01; **P < .001.