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. Author manuscript; available in PMC: 2007 Jul 24.
Published in final edited form as: Alcohol. 2006 Aug;40(1):19–33. doi: 10.1016/j.alcohol.2006.09.004

TABLE 2.

PKCγ wild-type expression changes due to chronic ethanol diet with fold change ≥ ±1.3; p < 0.05. Genes are divided in functional groups; p < 0.05.

Second Level GO Term Gene Name Gene Description Fold Change Sixth Level GO Term Genbank Accession Locuslink Accession Affymetrix Accession
Cellular Physiological Processes Prkcd Protein kinase C delta1,3,7 1.37 Protein serine/threonine kinase activity; amino acid phosphorylation X60304 18753 104531_at
Ank1 Ankyrin 1 erythroid 1,4,6 1.35 Transcription factor activity; cytoskeleton X69064 11733 10441_s_at
Edn1 Endothelin 11,2,3,6 1.89 G-protein coupled receptor protein signaling pathway U35233 13614 102737_at
Tle1 Transducin-like enhancer of split 1, homolog of Drosophila E(sp1)1,4,5,6 −1.32 Wnt receptor signaling pathway; regulation of transcription U61362 21885 102425_at
Egr1 Early growth response 11,4 1.42 Regulation of transcription M28845 13653 98579_at
Chd1 Chromodomain helicase DNA binding protein 1 1,4,5,7 1.4 Chromatin assembly/disassembly; ATP-dependent helicase activity L10410 12648 101459_at
Apaf1 Apoptotic protease activating factor 11,2,3,4,5,6,7 −1.41 Apoptosis; brain development; ATP binding AF064071 11783 103796_at
Sept6 Septin 61,7 1.33 GTP binding; cytokinesis AB023622 56526 92462_at
Tfrc Transferrin receptor1,4,5 −3.44 Endocytosis; iron ion transporter activity; proteolyisis/peptidolysis X57349 22042 X57349_5_at
Kcnk1 Potassium channel, subfamily K, member 11,4,5,6 −1.73 Potassium ion transport; integral to membrane AF033017 16525 102335_at
Dm15 Dystrophia myotonica kinase, B151,7 1.42 Protein serine/threonine kinase activity; meiosis Z38015 13401 93431_at
Mt3 Metallothionein 31,3,4,5 1.37 Metal ion binding; negative regulation of neurogenesis M93310 17751 95340_at
Alas2 Aminolevulinic acid synthase 2, erythroid1,5 −2.00 5-aminolevulinate syntahse activity; biosynthesis M15268 11656 92768_at
Dao1 D-amino acid oxidase1,4,5,7 1.38 Electron transport; tRNA aminoacylation for protein translation D10210 13142 103602_at
Lamp2 Lysosomal membrane glycoprotein 21,4,5,7 1.35 tRNA aminoacylation for protein translation; lysosome M32017 16784 100136_at
Clk CDC-like kinase1,4,5,7 −1.31 Protein sesrine/threonine kinase activity M38381 12747 93274_at
Klf4 Kruppel-like factor 4 (gut)1,4,5 1.53 Regulation of transcriptiom U20344 16600 99622_at
Max Max protein1,4,5,6 −1.32 Regulation of transcription M63903 17187 99095_at
Tcfap2b Transcription factor AP-2 beta1,4,5,6 1.33 Transcription factor activity; DNA binding X78197 21419 92903_at
Rad23b RAD23b homolog (S. cerevisiae)1,3,4,5 1.43 DNA repair; response to DNA damage X92411 19359 96102_at
Snrpd1 Small nuclear ribonucleoprotein D11,4 −1.64 mRNA processing; spliceosome complex M58558 20641 10057_at
Bpgm 2,3-bisphosphoglycerate mutase1 −1.34 Catalytic activity; phosphotransferases X13586 12183 94815_at
Sucla2 Succinate-Coenzyme A ligase, ADP-forming, beta subunit 1,4 −1.34 Catalytic activity; glycolysis AF058955 20916 93501_f_at
Impa1 Inositol (myo)-1(or4)-monophosphotase 11 −1.33 Myo-ionositol metabolism; magnesium ion binding AF042730 55980 101498_at
Ptp4a2 Protein tyrosine phosphatase 4a21 1.38 Protein amino acid dephosphorylation AF064071 11783 103796_at
C1qa Complement component 1,q subcomponent, alpha polypeptide1,3,5 1.42 Complement activation, classical pathway; extracellular space X58861 12259 98562_at
Response to Stress Crhr1 Corticotrophin releasing hormone receptor 13 −1.41 G-protein coupled receptor activity; membrane X72305 12921 95290_at
Intracellular/Intracelular Organelle Banp Btg3 associated nuclear protein4 −1.34 Putative transcription factor AF091234 53325 98512_at
Mybpc3 Myosin binding protein C, cardiac4,6 1.42 Actin binding; structural constituent of cytoskeleton AF059576 17868 160582_at
Ddx3y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked4,5,7 −2.75 ATP-dependent RNA helicase activity; nucleic acid binding AJ007376 26900 103842_at
Psme3 Proteaseome (prosome, macropain) 28 subunit, 34 1.38 Proteasome activator complex AB007139 19192 93803_at
Grb2 Growth factor receptor bound protein 24,5,6 1.38 RAS protein signal transduction U07617 14784 10134_at
Snca Synuclein, alpha1,4,6 −1.33 Cytoplasm AF044672 20617 93273_at
Lmna Lamin A1,4,6 1.35 Intermediate filament D49733 16905 98159_s_at
Cacybp Calcyclin binding protein1,4,5,6 −1.34 Molecular bridge U97327 12301 92596_at
Adk2 Adenylate kinase 21,4,5,7 1.64 Catalytic activity AB020202 11637 95148_at
Protein Binding Wbp2 WW domain binding protein 26 1.35 Binding protein U40826 22378 92683_at
Cldn5 Claudin 56 1.46 Integral to membrane U82758 12741 104516_at
Btg2 B-cell translocation gene 2, antiproliferative1,3,6 1.52 Antiproliferative protein M64292 12277 101583_at
No Assignment to Functional Group at GO Level 2 at p < 0.05 Nell2 Nel-like 2 homolog (chicken) 1.55 Calcium ion binding U59230 54003 92358_at
Plp Proteolipid protein (myelin) −1.59 Myelination; synaptic transmission M16472 18823 92802_s_at
Islr Immuoglobulin superfamily containing leucine-rich repeat 1.45 Extracellular space AB024538 26968 99010_at
C920001 C06Rik RIKEN cDNA C920001C06 gene 1.33 AB023622 92462_at

Functional groups as determined by DAVID Bioinformatics Functional Group Analysis (http://niaid.abcc.ncifcrf.gov/home.jsp):

1

Cellular Physiological Processes;

2

Tube Development;

3

Response to Stress;

4

Intracellular/Intracellular Organelle;

5

Membrane-Bound Organelle;

6

Protein Binding;

7

Nucleotide Binding.