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. 2007 Jul;176(3):1403–1415. doi: 10.1534/genetics.107.071621

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Copyright © 2007 by the Genetics Society of America

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Figure 6.— — Relationships among MMEJ, HR, NHEJ, and mismatch repair pathways in fission yeast. Rad22 and Exo1 proteins are required for EC MMEJ, suggesting that MMEJ is related to SSA. Rhp51 is involved in EC MMEJ only if continuous microhomologies are available for the repair. Pol4 is strictly required for repair involving the use of discontinuous microhomologies. Msh2 MMR protein is also involved in EC MMEJ at discontinuous microhomologous regions. Both types of EC MMEJ (continuous/discontinuous microhomologies) are inhibited by Pku70.