Table 1.
Potency and selectivity of caspase-3 inhibitors.
| Kiapp a (nM) | ||||
| Inhibitor | Caspase-3 | Caspase-7 | Caspase-8 | Caspase-9 |
| Ac-DEVD-CHO | 0.288 ± 0.087 | 4.48 ± 0.21 | 0.597 ± 0.095 | 1.35 ± 0.31 |
| Ac-DQTD-CHO | 1.27 ± 0.11 | 21.8 ± 1.1 | 9.75 ± 1.09 | 14.5 ± 0.7 |
| Ac-DMQD-CHO | 13.3 ± 0.3 | >200 | >200 | >200 |
| Ac-DNLD-CHO | 0.680 ± 0.163 | 55.7 ± 6.0 | >200 | >200 |
a Kiapp was calculated from the IC50 value, Kiapp = IC50/(1+ [S]/Km), where Km is the Michaelis constant of the substrate and [S] is the substrate concentration in the assay.