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. 2007 Aug 1;2(8):e698. doi: 10.1371/journal.pone.0000698

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Lenoir et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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a, the S-/C+ condition, or b, the S+/C+ condition. Locomotion (i.e., mean number of cage crossings±SEM) was measured during 10 min after the first cocaine self-injection (0.25 mg, i.v.) of the day (open triangle: day 1; closed circle: day 5; closed square: day 15). *, day 5 different from day 1; °, day 15 different from day 1 (P<0.05, Fisher's LSD test). c, Effects of the first cocaine self-injection in rats initially trained under the S+/C- condition and tested for the first time under the S+/C+ condition on day 16. These effects (open square) were compared to the effects of cocaine on day 15 in rats initially trained under the S+/C+ (closed square). *, P<0.05, Fisher's LSD test. The arrow in all graphs indicates the intravenous injection of cocaine.