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Levels of p53 in the skin of nontransgenic, E6- and E7-transgenic, and p53-null mice after treatment with radiation. Shown are high power magnifications (×400) of cross sections of skin from nontransgenic, K14HPV16E6 transgenic, and K14HPV16E7 transgenic mice stained immunohistochemically for p53. Mice were either not treated (a, c, e, and g) or treated with 5 Gy of ionizing radiation 24 hr prior to sacrifice (b, d, f, and h). Examples of p53-positive cells are indicated by arrows.
