Table 1.
Decreases in the levels of DNA synthesis after ionizing radiation in mouse epidermis
| Mouse strain | BrdUrd-positive cells,* %
|
P value | |
|---|---|---|---|
| Unirradiated | Irradiated | ||
| Nontransgenic | 4.52 ± 1.69 | 0.39 ± 0.59 | <0.001 |
| E6-transgenic | 5.64 ± 1.84 | 5.05 ± 1.83 | >0.05 |
| p53-null | 4.37 ± 2.05 | 2.86 ± 2.21 | <0.001 |
| E7-transgenic | 9.42 ± 3.21 | 8.40 ± 2.63 | >0.05 |
| E7ΔPTLHE-transgenic | 4.25 ± 2.29 | 0.40 ± 0.75 | <0.001 |
| E7ΔDLYC-transgenic | 5.50 ± 2.57 | 0.45 ± 0.66 | <0.001 |
*
Shown are the average percentage of BrdUrd-positive epidermal cells in unirradiated and irradiated mice (24 hr after irradiation). Data were obtained from analysis of paraffin-embedded skin sections stained for BrdUrd.