TABLE 2.
Comparison of parameter estimates for the population model with the results of 200 bootstrapped runs
| Parameter and model | Final model value | Bootstrap value (n = 200) (median [90% CI])b |
|---|---|---|
| Structural modela | ||
| CL/F (θ1; liters/h) | 3.02 | 3.01 (2.42-3.52) |
| V/F (θ2; liters) | 1,110 | 1,110 (874-1,382) |
| Ka (θ3; h−1) | 0.243 | 0.245 (0.212-0.280) |
| Weight centered on CL/Fc | 0.448 | 0.447 (0.249-0.816) |
| Weight centered on V/Fd | 0.713 | 0.713 (0.371-1.20) |
| Variance model | ||
| IIVCL/F (CV%) | 18 | 18 (16-20) |
| IIVV/F (CV%) | 22 | 22 (20-25) |
| IIVKa (CV%) | 76 | 75 (64-85) |
| IOVCL/F (CV%) | 18 | 18 (16-20) |
| RUV (CV%) | 5.9 | 5.9 (4.7-7.4) |
| RUV (ng/ml) | 22.9 | 23.1 (18.7-26.3) |
a
CL/F = θ1·(1 + θ4·WT/80.9); V/F = θ2·(1 + θ5·WT/80.9); Ka = θ3.
b
Percentile bootstrap 90% confidence interval (5th to 95th percentiles).
c
Linear coefficient (θ4) for weight centered on CL/F.
d
Linear coefficient (θ5) for weight centered on V/F.