TABLE 1.
Pharmacokinetics of rifampin at doses of 3 mg/kg, 6 mg/kg, and 12 mg/kg of body weight during a previous study (17) and at 20 mg/kg of body weight during the present studya
| RMP dose (mg/kg) | n | Cmax (μg/ml) | Tmax (h) | AUCI (μg·h/ml) |
|---|---|---|---|---|
| 3 | 8 | 2.53 (1.95) | 3.12 (2.63) | 13.1 (4.5) |
| 6 | 8 | 3.19 (1.58) | 3.67 (2.63) | 24.5 (8.8) |
| 12 | 8 | 13.0 (4.5) | 2.50 (2.46) | 100 (21) |
| 20 | 13 | 14.0 (4.7) | 3.27 (2.1) | 171 (56) |
a
Cmax, peak concentration; Tmax, time to peak concentration; AUCI, area under the concentration-time curve extrapolated to infinity. All values are means (standard deviations).