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Correlation between excision and the translocation status of HIV-1 RT. Combined excision/rescue reactions with (A) TFV- and (B) AZA-MP-terminated primers were performed in the presence of increasing concentrations of the next templated nucleotide (dCTP). The results were graphed together with the corresponding footprinting experiments shown in Fig. 2. The graphs point to an inverse correlation between rates of excision (▴) and the shift toward the posttranslocation state (▪).
