. 2007 May 14;51(8):2920–2928. doi: 10.1128/AAC.00186-07

TABLE 1.

Kinetics of primer rescue catalyzed by wild-type and S282T HCV NS5B

Enzyme	C analogue	k_rescue(C) (min⁻¹)^a	A analogue	k_rescue(A) (min⁻¹)^a	k_rescue(C)/k_rescue(A)
Wild-type NS5B	3′-Deoxy	0.151 ± 0.027	3′-Deoxy	0.019 ± 0.002	7.8
	2′-O-Me	0.168 ± 0.035	2′-O-Me	0.033 ± 0.007	5.1
	2′-C-Me	0.160 ± 0.001	2′-C-Me	0.027 ± 0.006	5.8
S282T mutant	3′-Deoxy	0.141 ± 0.007	3′-Deoxy	0.019 ± 0.004	7.5
	2′-O-Me	0.160 ± 0.040	2′-O-Me	0.035 ± 0.008	4.6
	2′-C-Me	0.169 ± 0.071	2′-C-Me	0.031 ± 0.015	5.5

k_rescue was determined as described in Materials and Methods. Data are means ± standard deviations determined for three independent experiments.