TABLE 1.
Antimicrobial susceptibility patterns of carbapenem-resistant K. pneumoniae strains 469 and 490 and their respective transformants
| Antimicrobial agent or enzyme | MIC (μg/ml)
|
||||
|---|---|---|---|---|---|
| K. pneumoniae 469 | Transformant 469 | K. pneumoniae 490 | Transformant 490 | E. coli GeneHogs | |
| Ampicillin/sulbactam | >32 | >32 | >32 | >32 | <4 |
| Ceftriaxone | >64 | >64 | >64 | 8 | <1 |
| Ceftazidime | >64 | >64 | >64 | 16 | <1 |
| Cefepime | >64 | 32 | >64 | 4 | <1 |
| Aztreonam | >64 | 32 | >64 | >64 | <1 |
| Piperacillin | >128 | >128 | >128 | >128 | <4 |
| Piperacillin/tazobactam | >128 | >128 | >128 | 64 | <4 |
| Ciprofloxacin | <0.25 | <0.25 | >4 | <0.25 | <0.25 |
| Amikacin | 4 | 16 | >64 | <2 | <2 |
| Gentamycin | >16 | >16 | 2 | <1 | <1 |
| Colistin | 0.25 | 0.064 | 0.25 | 0.064 | 0.064 |
| Imipenem | 16 | 4 | 32 | 4 | <0.25 |
| Meropenem | 8 | 4 | 32 | 2 | <0.25 |
| Ertapenem | 16 | 4 | 64 | 2 | <0.25 |
| Tigecycline | 2 | 0.5 | 2 | 0.5 | 0.016 |
| bla enzymes detected | KPC-2 OXA-4, CTX-M-10 | KPC-2 OXA-4, CTX-M-10 | KPC-3 TEM-1 | KPC-3 TEM-1 | None |