TABLE 2.
Comparison of patient pharmacokinetic variables between morbidly obese and normal-weight subjects
| Variable | Value for subject group
|
P value | |
|---|---|---|---|
| Morbidly obese (n = 7) | Normal weight (n = 7) | ||
| Total dose (mg) | 461 ± 61 | 236 ± 26 | 0.0001a |
| Cmax (mg/liter) | 67.3 ± 12.3 | 42.3 ± 11.9 | 0.029a |
| Cmax (mg/liter/kgTBW) | 0.61 ± 0.16 | 0.72 ± 0.18 | 0.41 |
| C24 (mg/liter) | 6.55 ± 2.31 | 3.39 ± 0.79 | 0.011a |
| AUC0-24 (mg·h/liter) | 494 ± 62 | 307 ± 54 | 0.002a |
| AUC0-24 (mg·h/liter/kgTBW) | 4.41 ± 0.85 | 5.25 ± 0.82 | 0.18 |
| AUC0-∞ (mg·h/liter) | 581 ± 104 | 346 ± 63 | 0.003a |
| AUC0-∞ (mg·h/liter/kgTBW) | 5.17 ± 1.11 | 5.90 ± 0.94 | 0.29 |
| V (liter) | 10.04 ± 2.04 | 7.69 ± 1.05 | 0.066 |
| V (liter/kgTBW) | 0.09 ± 0.01 | 0.13 ± 0.02 | 0.003a |
| V (liter/kgIBWb) | 0.19 ± 0.04 | 0.14 ± 0.02 | 0.033a |
| V (liter/kgFFWc) | 0.18 ± 0.03 | 0.18 ± 0.03 | 0.77 |
| CL (liter/h) | 0.82 ± 0.21 | 0.73 ± 0.14 | 0.34 |
| CL (liter/h/kgTBW) | 0.0071 ± 0.0013 | 0.012 ± 0.0020 | 0.002a |
| CL (liter/h/kgIBW) | 0.016 ± 0.0013 | 0.013 ± 0.0020 | 0.16 |
| CL (liter/h/kgFFW) | 0.015 ± 0.0034 | 0.016 ± 0.0030 | 0.60 |
| CLR (liter/h) | 0.50 ± 0.11 | 0.59 ± 0.28 | 0.38 |
| CLR (liter/h/kgTBW) | 0.0044 ± 0.0010 | 0.0095 ± 0.0036 | 0.003a |
| CLR (liter/h/kgIBW) | 0.0096 ± 0.0027 | 0.0099 ± 0.0034 | 0.79 |
| CLR (liter/h/kgFFW) | 0.0092 ± 0.0024 | 0.013 ± 0.0050 | 0.042 |
| kel (h−1) | 0.08 ± 0.01 | 0.09 ± 0.01 | 0.142 |
| t1/2 (h) | 8.68 ± 1.67 | 7.72 ± 0.76 | 0.134 |
| Protein binding (%) | 88.8 ± 1.6 | 90.0 ± 1.8 | 0.146 |
a
Significantly different between the two groups.
b
IBW was estimated as follows: 45.5 + 2.3 × number of inches over 5 feet.
c
FFW was determined using BIA.