Figure 3.

Agonist-stimulated inositol phosphate generation at human NK-3 receptor homolog (A) and human NK-3 receptor (B) CHO cell lines. Cells were prelabeled with [³H]myoinositol and agonist-stimulated inositol phosphate production was measured as described. The results shown here represent the mean ± SEM percent of maximum response from three independent experiments performed in duplicate. The maximum responses observed for the human NK-3 receptor homolog cell line ranged from 2.1- to 3.8-fold above basal levels, whereas for the human NK-3 receptor cell line the responses observed ranged from 5.6- to 6.7-fold above basal levels.