Table 1.

Summary of the IC₅₀ values of peptide agonist displacement of [³H]senktide and [¹²⁵I-MePhe⁷]NKB binding at the human NK-3 receptor and human NK-3 receptor homolog

Peptide	NK-3 receptor		NK-3 receptor homolog
	[3H]senktide	[125I-MePhe7]NKB	[3H]senktide	[125I-MePhe7]NKB
SP	2960  ± 60*	>10,000	4450  ± 390	>10,000
NKA	2390  ± 230	7250  ± 2300	9150  ± 2440	>10,000
NKB	13  ± 1*	17  ± 4**	>10,000	126  ± 27
Senktide	84  ± 5	312  ± 81	127  ± 26	211  ± 14
[MePhe7]NKB	5.3  ± 0.5*	12  ± 2*	12  ± 1	45  ± 6

The data reported for [³H]senktide competition is derived from the data shown in Fig. 2. 

^*Significantly different at P < 0.05 compared with that obtained at the NK-3 receptor homolog, using unpaired t test on logarithmically transformed data.