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Substrate selectivity of SafC. (A) l-Dopa is a better substrate than methyldopa, and only catechols are substrates. (B) Catechol, dopamine, and caffeic acid are also substrates, although caffeic acid lacks the strict regioselectivity of the other substrates. The associated plain text numbers indicate kinetic constants (kcat/Km [M−1 s−1]) or relative percent activities in comparison to that of l-dopa (see the text). Me, methyl.
