TABLE 2.

PD properties of various antibacterial classes

Killing/inhibition pattern	PAE	In vivo PK/PD parameter predicting efficacy	Antibiotic class(es)a
Time dependent	Minimal	%T>MIC	β-Lactams
	Minimal	AUC/MIC ratio	Linezolid*
	Prolonged	AUC/MIC ratio	Macrolides, lincosamides, tetracyclines
	Prolonged	Cmax/MIC ratio	Glycopeptides*
Concentration dependent	Minimal	AUC/MIC ratio	Polymyxins
	Prolonged	AUC/MIC ratio and/or Cmax/MIC ratio	Aminoglycosides, quinolones, streptogramins, ketolides, daptomycin

^a*, the PK/PD parameter predicting efficacy varies with the organism under study and the type of animal model (1, 88, 89).