FIG. 1.

Hepatic histopathology in low-passage A. phagocytophilum-infected mice (top panels) and high-passage A. phagocytophilum-infected mice (bottom panels). Note the larger inflammatory lesions (top left panel) and lobular infiltrates of predominantly lymphocytes and macrophages with edema, focal necrosis, and apoptotic cells (top right panel). The bottom panels show similar anatomic compartments with smaller inflammatory lesions and infiltrates and less hepatocyte injury. The preparations were stained with hematoxylin and eosin.