FIG. 4.

Lung P. carinii burden in C57BL/6 mice treated with anti-IL-23p19 Ab. C57BL/6 mice were inoculated with P. carinii and treated with either anti-IL-23 Ab or isotype control Ab twice a week. At the indicated time points postinoculation, total RNA was isolated from the right lungs for assay of P. carinii rRNA expression levels by real-time RT-PCR. The data are expressed as the means ± SEMs and are representative of two separate experiments. n = 4 per group. *, P < 0.05 compared with control mice at the same time point.