FIG. 11.

Effect of neutralizing antibodies on the circulating levels of BoNT/A. ¹²⁵I-labeled BoNT/A was incubated alone (open bars) or with antiserum (cross-hatched bars) from animals that had been immunized with trivalent mucosal vaccine (0.01 ml; 30 min; room temperature). Mice were injected intravenously with the material, and 30 min later samples of blood were collected. The results demonstrated that neutralizing antibodies resulted in a dramatic reduction in blood and serum levels of toxin.