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CD40LE parasites cause lesions in SCID mice. SCID mice on a BALB/c background were infected with 1 × 105 parasites in the right hind footpad. Lesion size was monitored, and parasite burdens were determined at the completion of the experiment (inset). Wild-type (open circles/bars) and CD40LE organisms (filled circles/bars) induced comparable lesions with similar numbers of parasites within them.
